AI Article Synopsis

  • The study focused on understanding how primary care clinicians prescribe direct anticoagulants (DOACs) like apixaban and rivaroxaban for the extended treatment of venous thromboembolism (VTE) and their dose reduction practices.
  • A survey was conducted with 227 clinicians to analyze their prescribing patterns, revealing that most (59%) used dose reduction, with hospitalists and early-career clinicians being the least likely to do so.
  • The research identified five distinct prescribing behavior clusters based on dose reduction frequency and clinician characteristics, suggesting areas for targeted interventions to improve anticoagulant management.

Article Abstract

The direct anticoagulants (DOACs), apixaban and rivaroxaban, are used for extended-phase treatment of venous thromboembolism (VTE) and have labeling for dose reduction for this indication. The objective of this study was to better understand primary care clinician prescribing patterns of apixaban and rivaroxaban for extended-phase anticoagulation. We conducted a 21-question survey targeting members of the American College of Physicians and United States Veterans Administration anticoagulation management services. Survey questions covered prescribing behaviors for dose reduction of apixaban and rivaroxaban for extended VTE treatment, as well as questions related to the respondent's practice setting. We used logistic regression to assess associations between demographics and prescribing behaviors. We used k-means clustering to identify distinct groups of prescribing patterns. Among 227 respondents, most were attending physicians (60%) and one-third (34%) practiced in internal medicine or primary care. Most (59%) indicated they dose-reduced DOACs. Hospitalists (no outpatient care) were least likely to dose-reduce (OR 0.09 [95% CI 0.03-0.22]), as well as early-career clinicians (0.53 [0.30-0.91]). Pharmacists and clinicians who treat over 500 VTE patients annually were most likely to dose reduce (6.4 [2.9-16.3]), (2.9 [1.5-6.0]), respectively. We identified five clusters of dosing behaviors and characterized clinician makeup. Clusters were primarily differentiated by frequency of dose reduction, DOAC preference, and temporary re-escalation of doses. We identified clinician characteristics that are associated with dose-reduction prescribing behaviors; these analyses provide insight into where targeted interventions, such as protocolization and education, would be most beneficial.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10779925PMC
http://dx.doi.org/10.3390/jcm13010096DOI Listing

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