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The Follow-Up Necessity in Human Papilloma Virus-Positive vs. Human Papilloma Virus-Negative Oral Mucosal Lesions: A Retrospective Study. | LitMetric

The Follow-Up Necessity in Human Papilloma Virus-Positive vs. Human Papilloma Virus-Negative Oral Mucosal Lesions: A Retrospective Study.

J Clin Med

Unit of Oral Pathology and Medicine and Odontostomatological Diagnostics, Section of Clinical Dentistry, Department of Neurosciences, University of Padova, 35122 Padova, Italy.

Published: December 2023

AI Article Synopsis

  • HPV is the main cause of cervical cancer and is also linked to head and neck cancers, particularly oropharyngeal cancer, but the connection with oral cancer remains debated.
  • The study aimed to investigate the need for different follow-up protocols for HPV-positive versus HPV-negative oral lesions and to assess the recurrence rates of HPV-related lesions.
  • Analyzing data from 230 patients, the findings showed that while there are no explicit follow-up recommendations for oral lesions, there is a significant difference in follow-up practices between HPV-positive and negative patients, along with a low recurrence rate for HPV-related oral lesions.

Article Abstract

Human papilloma virus (HPV) is known as the main cause of cervical cancer. Data also indicate its role in head-neck cancer, especially oropharyngeal cancer. The correlation between high-risk HPV and oral cancer is still controversial. HPV-related lesions of the oral cavity are frequent and, in most cases, benign. The primary aim of this study was to establish if there is a different follow-up necessity between HPV-positive compared to HPV-negative oral lesions. The secondary aim was to evaluate the recurrence of HPV-related lesions. All patients who underwent a surgical procedure of oral biopsy between 2018 and 2022, with ulterior histopathological examination and HPV typing, were examined. A total of 230 patients were included: 75 received traumatic fibroma as diagnosis, 131 HPV-related lesions, 9 proliferative verrucous leukoplakia, and 15 leukoplakia. The frequency and period of follow-up varied in relation to HPV positivity and diagnosis. This study confirms what has already been reported by other authors regarding the absence of recommendations of follow-up necessity in patients with oral mucosal lesions. However, the data demonstrate that there was a statistically significant difference in the sample analyzed regarding the follow-up of HPV-positive vs. HPV-negative patients. It also confirms the low recurrence frequency of HPV-related oral lesions.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10779469PMC
http://dx.doi.org/10.3390/jcm13010058DOI Listing

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