To evaluate the sound insulation capacity of small panels made of polymeric materials by 3D printing, a Taguchi L18-type factorial experiment with eight independent variables was designed and materialized. The independent variables were the panel thickness, polymer material type, 3D printing speed, infill percent, infill pattern, layer thickness, frequency, and sound volume. Empirical mathematical models were determined through the mathematical processing of the experimental results using specialized software. These empirical mathematical models highlight the meaning and intensity of the influence exerted by the input factors in the process on the acoustic pressure level of the energy absorbed after the passage of sounds through the small panels manufactured by 3D printing from polylactic acid and polyethylene terephthalate glycol. The factor with the strongest influence was the frequency of the sounds, with a maximum of the sound pressure level for a frequency of 13,000 Hz. A polylactic acid panel between the sound source and the sound-receiving sensor reduces the sound pressure level by about 45% from 95.8 to 65.8 dB. The power function type mathematical model in the case of the energy absorbed by the panel highlights the fact that the highest values of the exponents are those attached to the sound frequency (exponent equal to 1.616) and, respectively, to the thickness of the panel (exponent equal to -0.121).
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http://dx.doi.org/10.3390/polym16010005 | DOI Listing |
Int J Mol Sci
December 2024
Centro de Genética y Genómica, Instituto de Ciencias e Innovación en Medicina, Facultad de Medicina Clínica Alemana Universidad del Desarrollo, Santiago 7550000, Chile.
Targeted therapy indications for actionable variants in non-small-cell lung cancer (NSCLC) have primarily been studied in Caucasian populations, with limited data on Latin American patients. This study utilized a 52-genes next-generation sequencing (NGS) panel to analyze 1560 tumor biopsies from NSCLC patients in Chile, Brazil, and Peru. The RNA sequencing reads and DNA coverage were correlated to improve the detection of the actionable exon 14 skipping variant (METex14).
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National Cancer Institute, 08406 Vilnius, Lithuania.
Lung cancer is the second most common malignancy and stands as a leading cause of cancer-related deaths worldwide. Currently, one of the main treatment options for lung cancer is radiotherapy, but this treatment is associated with complications, such as an increased risk of cardiac-related morbidity and mortality. However, currently available methods for predicting radiation-induced heart disease (RIHD) remain suboptimal.
View Article and Find Full Text PDFBiomedicines
November 2024
Medical Oncology Unit, Fondazione IRCCS San Gerardo dei Tintori di Monza, 20900 Monza, Italy.
: The treatment landscape for non-small cell lung cancer (NSCLC) has evolved significantly with the advent of immunotherapy. Nonetheless, uncertainty regarding optimal first-line treatments, special populations, and the feasibility of rechallenge remains. This study aims to investigate Italian oncologists' opinions on these aspects through a Delphi Survey.
View Article and Find Full Text PDFBiomolecules
December 2024
Department of Anesthesiology, Virgen de la Victoria University Hospital, 29010 Malaga, Spain.
Background: The effects of anesthetic drugs on myocardial cells have been a subject of research for the last 50 years. The clinical benefits of halogenated agents, particularly sevoflurane, have been demonstrated in cardiac surgery patients. These benefits are due to the action of different enzymes and a variety of molecular pathways mediated by the action of small noncoding RNAs (sRNA) such as microRNAs (miRNAs).
View Article and Find Full Text PDFMol Ecol Resour
January 2025
Unit of Animal Genomics, GIGA-R & Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
In populations of small effective size (N), such as those in conservation programmes, companion animals or livestock species, inbreeding control is essential. Homozygosity-by-descent (HBD) segments provide relevant information in that context, as they allow accurate estimation of the inbreeding coefficient, provide locus-specific information and their length is informative about the "age" of inbreeding. Our objective was to evaluate tools for predicting HBD in future offspring based on parental genotypes, a problem equivalent to identifying segments identical-by-descent (IBD) among the four parental chromosomes.
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