AI Article Synopsis
- Amyotrophic Lateral Sclerosis (ALS) is a serious neurodegenerative disease that leads to the progressive loss of motor neurons, making it challenging to find effective treatments due to unclear cellular signaling mechanisms.
- A particular model organism has proven useful for studying ALS at the molecular level, offering insights into genetic factors, protein aggregation, and cellular processes related to the disease.
- The review assesses the strengths and limitations of this model in ALS research and suggests future studies to enhance the translation of basic discoveries into clinical solutions.
Article Abstract
Amyotrophic Lateral Sclerosis (ALS) is a debilitating neurodegenerative condition characterized by the progressive degeneration of motor neurons. Despite extensive research in various model animals, the cellular signal mechanisms of ALS remain elusive, impeding the development of efficacious treatments. Among these models, a well-characterized and diminutive organism, (), has emerged as a potent tool for investigating the molecular and cellular dimensions of ALS pathogenesis. This review summarizes the contributions of models to our comprehension of ALS, emphasizing pivotal findings pertaining to genetics, protein aggregation, cellular pathways, and potential therapeutic strategies. We analyze both the merits and constraints of the system in the realm of ALS research and point towards future investigations that could bridge the chasm between foundational discoveries and clinical applications.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10778397 | PMC |
| http://dx.doi.org/10.3390/cells13010099 | DOI Listing |
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