AI Article Synopsis
- The study looked at how stopping cannabis use can cause psychotic symptoms, which wasn't studied much before.
- Researchers gathered information from patients who showed these symptoms when they stopped using cannabis in Montreal from 2020 to 2023.
- They found eight patients with serious symptoms during withdrawal, and this research helps understand how cannabis affects the brain.
Article Abstract
Objectives: The link between cannabis use and psychotic symptoms or disorders is well known. However, the relation between cannabis withdrawal and psychotic symptoms is less studied.
Methods: To our knowledge, this is the first publication of an observational systematic report of cannabis-induced psychotic disorder with onset during withdrawal. Here, we review patients presenting to a major emergency room in Montreal between January 2020 and September 2023 in a context of psychotic symptoms following cannabis cessation.
Results: In total, seven male and one female patients presented at the peak of cannabis withdrawal with acute psychotic symptoms, representing less than 1% of all emergency service admissions.
Conclusions: We discuss current knowledge regarding the endocannabinoid system and dopamine homeostasis to formulate hypotheses regarding these observations.
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| http://dx.doi.org/10.1017/neu.2023.60 | DOI Listing |
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