AI Article Synopsis
- This study investigated the genetic factors associated with immunoglobulin E (IgE) levels in a Taiwanese Han population, revealing eight significant genomic variants linked to IgE synthesis and atopic diseases.
- Two novel SNPs were identified, with the CD28 SNP, rs1181388, and an intergenic SNP on chromosome 11 showing strong associations to IgE levels.
- The research emphasizes the potential of IgE polygenic risk scores (PRS) in predicting allergic reactions and their correlation with conditions like asthma and atopic dermatitis, enhancing our understanding of IgE regulation through genetic variants.
Article Abstract
Immunoglobulin E (IgE) synthessis is highly related to a variety of atopic diseases, and several genome-wide association studies (GWASs) have demonstrated the association between genes and IgE level. In this study, we conducted the largest genome-wide association study of IgE involving a Taiwanese Han population. Eight independent variants exhibited genome-wide significance. Among them, an intronic SNP of CD28, rs1181388, and an intergenic SNP, rs1002957030, on 11q23.2 were identified as novel signals for IgE. Seven of the loci were replicated successfully in a meta-analysis using data on Japanese population. Among all the human leukocyte antigen (HLA) regions, HLA-DQA1*03:02 - HLA-DQB1*03:03 was the most significant haplotype (OR = 1.25, SE = 0.02, FDR = 1.6 × 10), corresponding to HLA-DQA1 Asp160 and HLA-DQB1 Leu87 amino acid residues. The genetic correlation showed significance between IgE and allergic diseases including asthma, atopic dermatitis, and pollinosis. IgE PRS was significantly correlated with total IgE levels. Furthermore, the top decile IgE polygenic risk score (PRS) group had the highest risk of asthma for the Taiwan Biobank and Biobank Japan cohorts. IgE PRS may be used to aid in predicting the occurrence of allergic reactions before symptoms occur and biomarkers are detectable. Our study provided a more comprehensive understanding of the impact of genomic variants, including complex HLA alleles, on serum IgE levels.
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| http://dx.doi.org/10.1016/j.clim.2024.109897 | DOI Listing |
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