Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3967/bes2023.152 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode.
Nat Commun
December 2024
Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
By targeting the essential viral RNA-dependent RNA polymerase (RdRP), nucleoside analogs (NAs) have exhibited great potential in antiviral therapy for RNA virus-related diseases. However, most ribose-modified NAs do not present broad-spectrum features, likely due to differences in ribose-RdRP interactions across virus families. Here, we show that HNC-1664, an adenosine analog with modifications both in ribose and base, has broad-spectrum antiviral activity against positive-strand coronaviruses and negative-strand arenaviruses.
View Article and Find Full Text PDFMolecular characterization of antibiotic resistance in bacteria from daycare centres in Ile-Ife, Nigeria.
JAC Antimicrob Resist
February 2025
Department of Microbiology, Obafemi Awolowo University, Ife, Osun, Nigeria.
Background: Antibiotic resistance is an escalating global health issue, with particularly severe implications in low- and middle-income countries (LMICs) such as Nigeria. This study examines antibiotic-resistant bacteria's prevalence and molecular characteristics in daycare centres in Ile-Ife, Nigeria, where high antibiotic use and limited infection control measures present significant challenges.
Methods: Between November 2017 and July 2019, samples were collected from 20 daycare centres, including swabs from fomites and children.
Regulation of epidermal barrier function and pathogenesis of psoriasis by serine protease inhibitors.
Front Immunol
December 2024
Shanxi Key Laboratory of Stem Cells for Immunological Dermatosis, Institute of Dermatology, Taiyuan Central Hospital, Taiyuan, China.
Serine protease inhibitors (Serpins) are a protein superfamily of protease inhibitors that are thought to play a role in the regulation of inflammation, immunity, tumorigenesis, coagulation, blood pressure and cancer metastasis. Serpins is enriched in the skin and play a vital role in modulating the epidermal barrier and maintaining skin homeostasis. Psoriasis is a chronic inflammatory immune-mediated skin disease.
View Article and Find Full Text PDFPomegranate peel extract diet enhances health and immunity of common carp () against .
Open Vet J
November 2024
Department of Fisheries and Marine Resources, Collage of Agriculture, Basrah University, Basrah, Iraq.
Background: Pomegranate () fruit rich in bioactive constituents, is used as a feed supplement against bacterial pathogens in aquaculture.
Aim: This study examined the effects of supplementing the diet of the common carp () infected with on growth and some hematological, biochemical, and immunological health indicators.
Methods: Carp was fed for 7 weeks a diet of 30% crude protein and 7% crude fat, supplemented with 0, 0.
Whole-genome sequencing and genomic analysis of four strains newly isolated from human feces.
Front Microbiol
December 2024
West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Background: Numerous studies have demonstrated that is closely associated with human health. These bacteria colonize the mucus layer of the gastrointestinal tract and utilize mucin as their sole source of carbon and nitrogen. spp.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!