Phys Med Biol
University of Applied Sciences, Institute of Medical Physics and Radiation Protection, Giessen, Germany.
Published: January 2024
To compare two independently developed methods that enable modelling inter-track interactions in TOPAS-nBio by examining the yield of radiolytic species in radiobiological Monte Carlo track structure simulations. One method uses a phase space file to assign more than one primary to one event, allowing for inter-track interaction between these primary particles. This method has previously been developed by this working group and published earlier. Using the other method, chemical reactions are simulated based on a new version of the independent reaction time approach to allow inter-track interactions.-values were calculated and compared using both methods for different numbers of tracks able to undergo inter-track interactions.Differences in the-values simulated with the two methods strongly depend on the molecule type, and deviations can range up to 3.9% (HO), although, on average, the deviations are smaller than 1.5%.Both methods seem to be suitable for simulating inter-track interactions, as they provide comparable-values even though both techniques were developed independently of each other.
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http://dx.doi.org/10.1088/1361-6560/ad1cf4 | DOI Listing |
Phys Med Biol
January 2025
School of Physics, Mathematics & Computing, University of Western Australia, Crawley, Western Australia, Australia.
FLASH radiotherapy employs ultra-high dose rates of>40Gy s, which may reduce normal tissue complication as compared to conventional dose rate treatments, while still ensuring the same level of tumour control. The potential benefit this can offer to patients has been the cause of great interest within the radiation oncology community, but this has not translated to a direct understanding of the FLASH effect. The oxygen depletion and inter-track interaction hypotheses are currently the leading explanations as to the mechanisms behind FLASH, but these are still not well understood, with many questions remaining about the exact underpinnings of FLASH and the treatment parameters required to optimally induce it.
View Article and Find Full Text PDFPhys Med Biol
January 2024
University of Applied Sciences, Institute of Medical Physics and Radiation Protection, Giessen, Germany.
Sci Rep
July 2023
Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7AE, UK.
Phys Med Biol
June 2023
University of Applied Sciences, Institute of Medical Physics and Radiation Protection, Giessen, Germany.
In FLASH radiotherapy (dose rates ≥40 Gy s), a reduced normal tissue toxicity has been observed, while maintaining the same tumor control compared to conventional radiotherapy (dose rates ≤0.03 Gy s). This protecting effect could not be fully explained yet.
View Article and Find Full Text PDFPhys Med
June 2023
Institute of Radiation Physics (IRA), Lausanne University Hospital and University of Lausanne, CH-1007 Lausanne, Switzerland. Electronic address:
FLASH radiotherapy is a promising approach to cancer treatment that offers several advantages over conventional radiotherapy. With this novel technique, high doses of radiation are delivered in a short period of time, inducing the so-called FLASH effect - a phenomenon characterized by healthy tissue sparing without alteration of tumor control. The mechanisms behind the FLASH effect remain unknown.
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