AI Article Synopsis
- Sjögren's Disease (SjD) is an autoimmune disorder affecting salivary glands, but the cause and effective treatments are still unclear.
- Researchers used advanced techniques like single-cell and spatial transcriptomics to analyze both healthy and diseased salivary glands, revealing key differences in cellular composition.
- The study found that specific immune cells, particularly +CD8 T cells, are involved in damaging secretory cell types in SjD, highlighting the complex immune interactions that contribute to the disease's progression.
Article Abstract
Sjögren's Disease (SjD) is a systemic autoimmune disease without a clear etiology or effective therapy. Utilizing unbiased single-cell and spatial transcriptomics to analyze human minor salivary glands in health and disease we developed a comprehensive understanding of the cellular landscape of healthy salivary glands and how that landscape changes in SjD patients. We identified novel seromucous acinar cell types and identified a population of - seromucous acinar cells that are particularly targeted in SjD. Notably, +CD8 T cells, enriched in SjD, exhibited a cytotoxic phenotype and were physically associated with immune-engaged epithelial cells in disease. These findings shed light on the immune response's impact on transitioning acinar cells with high levels of secretion and explain the loss of this specific cell population in SjD. This study explores the complex interplay of varied cell types in the salivary glands and their role in the pathology of Sjögren's Disease.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10775371 | PMC |
| http://dx.doi.org/10.21203/rs.3.rs-3601404/v1 | DOI Listing |
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