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Microphysiological system to address the opioid crisis: A novel multi-organ model of acute opioid overdose and recovery.
Curr Res Toxicol
December 2024
University of Central Florida, NanoScience Technology Center, 12424 Research Parkway, Suite 400, Orlando, FL 23826, United States.
Opioids have been the primary method used to manage pain for hundreds of years, however the increasing prescription rate of these drugs in the modern world has led to a public health crisis of overdose related deaths. Naloxone is the current standard treatment for opioid overdose rescue, but it has not been fully investigated for potential off-target toxicity effects. The current methods for pharmaceutical development do not correlate well with pre-clinical animal studies compared to clinical results, creating a need for improved methods for therapeutic evaluation.
View Article and Find Full Text PDFColon Cancer Rates Among Asian Americans: A 2017-2021 Epidemiological Analysis.
Cancers (Basel)
December 2024
Department of Family Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA.
Colon cancer (CC) is a significant public health concern. With Asian Americans (AAs) representing a rapidly growing demographic in the United States, our study examined CC prevalence among AAs. The study merged the 2017-2021 Medical Expenditure Panel Survey and County Health Ranking.
View Article and Find Full Text PDFAntimycobacterial and Anticancer Properties of Leaf Extract.
Pharmaceuticals (Basel)
July 2024
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, P.O. Box 3665, Abha 61421, Saudi Arabia.
Background: Plant-derived products or extracts are widely used in folk/traditional medicine to treat several infections, ailments, or disorders. A well-known medicinal herb, is an evergreen fragrant plant native to the Mediterranean region that has been used for ages in traditional medicine around the world.
Materials And Methods: The microplate alamarBlue assay and the well diffusion method were used to evaluate the zone of inhibition and MIC, respectively.
Floxed Locus with mCherry Reporter Element Reveals Distinct Expression Patterns of the IL-36 Receptor in Barrier Tissues.
Cells
May 2024
Department of Microbiology, Immunology and Inflammation, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA.
IL-36 cytokines are emerging as beneficial in immunity against pathogens and cancers but can also be detrimental when dysregulated in autoimmune and autoinflammatory conditions. Interest in targeting IL-36 activity for therapeutic purposes is rapidly growing, yet many unknowns about the functions of these cytokines remain. Thus, the availability of robust research tools is essential for both fundamental basic science and pre-clinical studies to fully access outcomes of any manipulation of the system.
View Article and Find Full Text PDFA new Neu-a syngeneic model of spontaneously metastatic HER2-positive breast cancer.
Clin Exp Metastasis
October 2024
Department of Medicine, Division of Medical Oncology, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Ave, Suite 6412, Los Angeles, CA, 90033, USA.
Article Synopsis
- Metastatic disease, a major cause of death in advanced breast cancer, involves tumor cells spreading from their original site to distant organs, highlighting the importance of studying these processes.
- Researchers have developed a new murine breast tumor cell line, NT2.5-LM, that shows a much faster spread of metastases after implantation, making it a valuable tool for understanding cancer progression and treatment.
- The NT2.5-LM cell line displays characteristics of enhanced metastatic potential, responds well to HER2-targeted therapies, and offers advantages over previous models, enabling better exploration of therapeutic strategies and mechanisms of metastasis.
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