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Mitochondrial transplantation normalizes transcriptomic and proteomic shift associated with ischemia reperfusion injury in neonatal hearts donated after circulatory death.
Sci Rep
December 2024
Department of Cardiac Surgery, Boston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA.
Heart transplantation remains the ultimate treatment strategy for neonates and children with medically refractory end-stage heart failure and utilization of donors after circulatory death (DCD) can expand th donor pool. We have previously shown that mitochondrial transplantation preserves myocardial function and viability in neonatal swine DCD hearts to levels similar to that observed in donation after brain death (DBD). Herein, we sought to investigate the transcriptomic and proteomic pathways implicated in these phenotypic changes using ex situ perfused swine hearts.
View Article and Find Full Text PDFDexmedetomidine therapy promotes cardiac dysfunction and increases mortality in sepsis: A translational study.
Int Immunopharmacol
December 2024
Department of Critical Care Medicine, the First Affiliated Hospital of Jinan University, Guangzhou 510632, Guangdong, China. Electronic address:
Previous studies demonstrated that dexmedetomidine (Dex) posttreatment aggravated myocardial dysfunction and reduced survival in septic mice. Yet, whether Dex elicits similar effects in septic patients as defined by Sepsis-3 remains unknown. This study sought to assess the effects of Dex-based sedation on mortality and cardiac dysfunction in septic patients defined by Sepsis-3 and to further reveal the mechanisms in septic rats.
View Article and Find Full Text PDFInvestigation Myocardial Perfusion Scan Parameters and Walls Motion in Patients undergoing Cardiac Surgery.
J Biomed Phys Eng
December 2024
Department of Medical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Background: Coronary heart disease the most prevalent form of cardiovascular disease, results from the blockage of blood flow through arteries. The Myocardial Perfusion Scan (MPS) is considered a non-invasive method to assess the heart condition and provides valuable information, such as End Diastolic Volume (EDV), End Systolic Volume (ESV), Ejection Fraction (EF), Lung to Heart Ratio (LHR), and Transient Ischemic Dilatation (TID).
Objective: This study aimed to investigate changes in gated heart scan parameters to diagnose patients, who are candidates for heart surgery.
Haemodynamic and hyperaemic effects of adenosine in patients with atrial fibrillation undergoing quantitative myocardial perfusion cardiovascular magnetic resonance.
Eur Heart J Imaging Methods Pract
July 2024
Department of Cardiovascular Sciences, University of Leicester and the National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester LE3 9QP, UK.
Aims: Patients with atrial fibrillation (AF) are thought to have an attenuated response to adenosine during vasodilator stress testing. We sought to investigate the haemodynamic and hyperaemic effects of adenosine in patients with AF undergoing adenosine-stress cardiovascular magnetic resonance (CMR) assessment.
Methods And Results: We retrospectively examined 318 patients referred for clinical adenosine-stress CMR (AF = 158, sinus rhythm [SR] = 160).
Comparative analysis of clinico-metabolic profiles between St Thomas and del Nido cardioplegia solutions: A pilot study.
Perfusion
December 2024
Department of Advanced Spectroscopy and Imaging, Centre of Biomedical Research, Lucknow, India and Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Introduction: Cardioplegia (CP) is integral to myocardial protection during cardiac surgery. Two standard cardioplegic solutions viz. Del Nido solution (DNS) and St Thomas solution (STS) are widely used in cardiac surgeries.
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