In the current paper, we consider a predator-prey model where the predator is modeled as a generalist using a modified Leslie-Gower scheme, and the prey exhibits group defense via a generalized response. We show that the model could exhibit finite-time blow-up, contrary to the current literature [Patra et al., Eur. Phys. J. Plus 137(1), 28 (2022)]. We also propose a new concept via which the predator population blows up in finite time, while the prey population quenches in finite time; that is, the time derivative of the solution to the prey equation will grow to infinitely large values in certain norms, at a finite time, while the solution itself remains bounded. The blow-up and quenching times are proved to be one and the same. Our analysis is complemented by numerical findings. This includes a numerical description of the basin of attraction for large data blow-up solutions, as well as several rich bifurcations leading to multiple limit cycles, both in co-dimension one and two. The group defense exponent p is seen to significantly affect the basin of attraction. Last, we posit a delayed version of the model with globally existing solutions for any initial data. Both the ordinary differential equation model and the spatially explicit partial differential equation models are explored.
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Am J Ind Med
January 2025
Defense Health Agency, Armed Forces Health Surveillance Division, Silver Spring, Maryland, USA.
Objective: This study examines the incidence of injuries among active component service members in Military Working Dog (MWD) handler occupations compared to three other active component occupational groups.
Methods: A retrospective cohort study was conducted with a total of 2,524,092 active component service members including, 3935 MWD handlers, 2025 veterinary personnel, 113,413 military police, and 2,404,719 all other active component service members (ACSM). Incidence rate and incident rate ratios of injuries were determined.
Biomark Res
January 2025
BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Sciences, School of Medicine, Kyungpook National University, Daegu, 41944, Korea.
Macrophages are pivotal in the body's defense and response to inflammation. They are present in significant numbers and are widely implicated in various diseases, including cancer. While molecular and histological techniques have advanced our understanding of macrophage biology, their precise function within the cancerous microenvironments remains underexplored.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Department of Chinese Osteo-traumatology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, China. Electronic address:
Fatigue is a pathological state that can impair physical and cognitive performance, making the development of effective therapeutic strategies crucial. In this study, an acid polysaccharide (MHa) was isolated from Mentha haplocalyx. Structural analysis showed that MHa (40.
View Article and Find Full Text PDFCrit Rev Oncol Hematol
January 2025
Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA. Electronic address:
There is a much debate regarding optimal selection in patients with metastatic cancer who should undergo local treatment (surgery or radiation treatment) to the primary tumor and/or metastases. Additionally, the optimal treatment of newly diagnosed metastatic cancer is largely unclear. Current prognostication systems to best inform these clinical scenarios are limited, as all metastatic patients are grouped together as having Stage IV disease without further incorporation of patient and disease-specific covariates that significantly impact patient outcomes.
View Article and Find Full Text PDFCardiovasc Toxicol
January 2025
Department of Morphological Sciences, State University of Maringa, Maringa, Parana, Brazil.
5-Fluorouracil (5-FU) is a chemotherapeutic that is used to treat solid tumors. However, 5-FU is associated with several side effects, including cardiotoxicity. Considering the importance of the intrinsic cardiac nervous system (ICNS) for the heart and that little is known about effects of 5-FU on this nervous system plexus, the purpose of the present study was to evaluate effects 5-FU at a low dose on the ICNS and oxidative and inflammatory effects in the heart in Wistar rats.
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