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The functional role of oscillatory dynamics in neocortical circuits: A computational perspective.
Proc Natl Acad Sci U S A
January 2025
Ernst Strüngmann Institute, Frankfurt am Main 60528, Germany.
The dynamics of neuronal systems are characterized by hallmark features such as oscillations and synchrony. However, it has remained unclear whether these characteristics are epiphenomena or are exploited for computation. Due to the challenge of selectively interfering with oscillatory network dynamics in neuronal systems, we simulated recurrent networks of damped harmonic oscillators in which oscillatory activity is enforced in each node, a choice well supported by experimental findings.
View Article and Find Full Text PDFLiving with pulmonary arterial hypertension: a patient's perspective on dyspnoea crises.
Breathe (Sheff)
January 2025
European Lung Foundation, Sheffield, UK.
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View Article and Find Full Text PDFGenetic insights and therapeutic avenues: unraveling the role of polyunsaturated fatty acids as mediators between hypothyroidism and Von Willebrand disease through Mendelian randomization.
Front Genet
January 2025
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Background: Previous observational studies have shown that Hypothyroidism is associated with Von Willebrand Disease (VWD), but the causal relationship has not been confirmed because of conflicting findings and confounding by mixing factors. There are also some studies suggesting that polyunsaturated fatty acids (PUFA) may be one of the potential mediators. In this study, we used a Mendelian randomization study to analyze the causal relationship between Hypothyroidism and VWD and to investigate whether polyunsaturated fatty acids mediate the effects of Hypothyroidism on VWD.
View Article and Find Full Text PDFPolicy options for sustainable access to off-patent antibiotics in Europe.
NPJ Antimicrob Resist
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LSE Health, Department of Health Policy, London School of Economics and Political Science, London, UK.
Securing sustainable access to existing antibiotics optimises agent choice for individual treatments and is crucial to curb antibiotic resistance. Access to antibiotics is often restricted in many countries, due to general market unavailability or episodic shortages. This article outlines key policy options to maintain availability of existing antibiotics and enhance antibiotic supply chain resilience focusing on the perspectives of European Union (EU) and European Economic Area (EEA) institutions and member states.
View Article and Find Full Text PDFFactors Relating to Sprint Swimming Performance: A Systematic Review.
Sports Med
January 2025
Aquatics Lab, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain.
Background: Swimming performance depends on a wide variety of factors; however, the interaction between these factors and their importance varies between events. In sprint events, the characterized pacing underlines its specific development, as swimmers must achieve the highest possible speed while sustaining it to the greatest extent possible.
Objectives: The aim of this review was to identify the key factors underlying sprint swimming performance and to provide in-depth and practical evidence-based information to optimize performance.
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