AI Article Synopsis
- The study investigates ocular signs and symptoms in participants from the Sjögren's International Collaborative Clinical Alliance cohort, comparing those with and without Sjögren's disease (SjD).
- Out of 3,380 participants, it was found that while ocular symptoms were similar between SjD and non-SjD groups, SjD participants had significantly higher ocular staining scores and were more likely to show specific ocular abnormalities.
- The findings suggest that SjD correlates with increased ocular pathology, and particular corneal staining patterns may serve as useful biomarkers for SjD-related dryness.
Article Abstract
Purpose: To examine the ocular signs and symptoms in participants of the Sjögren's International Collaborative Clinical Alliance cohort, and to compare them across Sjögren's disease (SjD) status.
Methods: Our study population comprised 3380 Sjögren's International Collaborative Clinical Alliance participants who had no missing data relevant to this study. Participants' SjD status was assessed using the updated 2016 American College of Rheumatism/European League Against Rheumatism SjD classification criteria. Participants completed baseline questionnaires of ocular symptoms and underwent ocular examinations. Differences in the ocular signs and symptoms between SjD and non-SjD groups were assessed. We used multivariable linear and linear mixed-effects models to investigate the impact of SjD on Ocular Surface Disease Index-6 and OSS.
Results: Among 1532 participants classified as SjD, their Ocular Surface Disease Index-6 did not clinically differ from those classified as non-SjD (adjusted difference, -0.97; 95% confidence interval, -1.52 to -0.41). However, SjD participants exhibited an elevated ocular staining score (adjusted difference, 3.47; 95% confidence interval, 3.36-3.57; P < 0.001) compared with non-SjD participants. In addition, SjD was associated with increased odds of ocular signs, such as reduced tear break-up time, abnormal Schirmer I test, and corneal abnormalities, and was strongly related to more intense corneal and conjunctival staining, as well as additional corneal staining points.
Conclusions: SjD is associated with a higher risk of ocular signs and pathology compared with non-SjD, whereas ocular symptoms remain similar. In addition, corneal abnormalities and corneal staining patterns could serve as a potential biomarker in identifying SjD-related dry eye.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10784845 | PMC |
| http://dx.doi.org/10.1167/iovs.65.1.23 | DOI Listing |
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