Bioactive neolignan, iridoid and flavonoid glycosides from the leaves of .

J Asian Nat Prod Res

School of Biological Science and Technology, University of Jinan, Jinan 250022, China.

Published: June 2024

AI Article Synopsis

  • - Two new types of compounds, neolignan glycosides and iridoid glycosides, were discovered in the leaves of a specific plant, along with nine flavonoid glycosides, using advanced analysis techniques like NMR and ESIMS.
  • - The unique structure of one of the neolignan glycosides was verified through chemical breakdown and ECD calculations, confirming its absolute stereochemistry.
  • - Some of these isolated compounds displayed antiradical activity and were found to reduce reactive oxygen species (ROS) levels in certain cells, showing potential neuroprotective effects.

Article Abstract

Two neolignan glycosides including a new one (), along with seven iridoid glycosides (-) and nine flavonoid glycosides (-), were isolated from the leaves of . Their structures were established mainly on the basis of 1D/2D NMR and ESIMS analyses, as well as comparison to known compounds in the literature. The structure of with absolute stereochemistry was also confirmed by chemical degradation and ECD calculation. Selective compounds showed antiradical activity against ABTS and/or DPPH. Moreover, several isolates also suppressed the production of ROS in RAW264.7 cells and exerted neuroprotective effect toward PC12 cells.

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Source
http://dx.doi.org/10.1080/10286020.2023.2299781DOI Listing

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