AI Article Synopsis
- - A study was conducted to understand the metabolic changes in urine of patients with severe fever with thrombocytopenia syndrome (SFTS) by comparing affected individuals to a healthy control group, ruling out other medical conditions.
- - The results highlighted that alterations in tryptophan and phenylalanine metabolism could differentiate between SFTS patients and healthy controls, with specific metabolites linked to the severity of the disease.
- - These findings suggest that targeting metabolic pathways related to tryptophan and phenylalanine could help in understanding SFTS better and developing potential treatments.
Article Abstract
Background: The pathogenesis of severe fever with thrombocytopenia syndrome (SFTS) remained unclear. We aimed to profile the metabolic alterations in urine of SFTS patients and provide new evidence for its pathogenesis.
Methods: A case-control study was conducted in the 154th hospital in China. Totally 88 cases and 22 controls aged ≥ 18 years were enrolled. The cases were selected from laboratory-confirmed SFTS patients. The controls were selected among SFTSV-negative population. Those with diabetes, cancer, hepatitis and other sexually transmitted diseases were excluded in both groups. Fatal cases and survival cases were 1:1 matched. Inter-group differential metabolites and pathways were obtained, and the inter-group discrimination ability was evaluated.
Results: Tryptophan metabolism and phenylalanine metabolism were the top one important metabolism pathway in differentiating the control and case groups, and the survival and fatal groups, respectively. The significant increase of differential metabolites in tryptophan metabolism, including 5-hydroxyindoleacetate (5-HIAA), L-kynurenine (KYN), 5-hydroxy-L-tryptophan (5-HTP), 3-hydroxyanthranilic acid (3-HAA), and the increase of phenylpyruvic acid and decrease of hippuric acid in phenylalanine metabolism indicated the potential metabolic alterations in SFTSV infection. The increase of 5-HIAA, KYN, 5-HTP, phenylpyruvic acid and hippuric acid were involved in the fatal progress of SFTS patients.
Conclusions: Tryptophan metabolism and phenylalanine metabolism might be involved in the pathogenesis of SFTSV infection. These findings provided new evidence for the pathogenesis and treatment of SFTS.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10775654 | PMC |
| http://dx.doi.org/10.1186/s12985-024-02285-2 | DOI Listing |
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