Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10801848 | PMC |
| http://dx.doi.org/10.1073/pnas.2321815121 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Performance of molecular classification in predicting oncologic outcomes of fertility-sparing treatment for atypical endometrial hyperplasia and endometrial cancer.
Int J Gynecol Cancer
January 2025
Nazionale dei Tumori di Milano, Fondazione IRCCS Istituto Gynecological Oncology Unit, Milan, Italy.
Objective: Endometrial cancers can be classified into 4 molecular sub-groups: (1) POLE mutated (POLEmut), (2) mismatch repair deficiency/microsatellite-instable (MMRd/MSI-H), (3) TP53-mutant or p53 abnormal (p53abn), and (4) no specific mutational profile (NSMP). Although molecular classification is increasingly applied in oncology, its role in guiding fertility-sparing treatments for endometrial cancer remains unclear. This study examines the prognostic role of molecular classification in fertility-sparing treatment and its potential to guide treatment decisions.
View Article and Find Full Text PDFClash of the Titans: the first multi-center retrospective comparative study between da Vinci and Hugo RAS surgical systems for the treatment of deep endometriosis.
Minim Invasive Ther Allied Technol
December 2024
Dipartimento di Scienze per la Salute della Donna e del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, UOC Ginecologia Oncologica, Rome, Italy.
Background: The proliferation of several robotic platforms presents an opportunity to pinpoint the most suitable system for specific procedures and patient profiles. This study aims to explore differences in complications and functional outcomes among patients undergoing deep endometriosis excision with the da Vinci surgical system compared to the Hugo RAS system.
Method: This is a retrospective, multicenter cohort study.
Safety and efficacy of adipose-derived mesenchymal stem cell therapy in elderly Parkinson's disease patients: an intermediate-size expanded access program.
Cytotherapy
February 2025
Hope Biosciences Research Foundation, Sugar Land, Texas, USA; Hope Biosciences, Sugar Land, Texas, USA.
Objective: This intermediate-size expanded access program aimed to evaluate safety and clinical efficacy of multiple intravenous infusions of autologous, Hope Biosciences adipose-derived mesenchymal stem cell (HB-adMSC) therapy in elderly patients with Parkinson's disease (PD).
Methods: Ten eligible participants (aged 76-95 years) received six intravenous infusions each with 200MM autologous HB-adMSCs over 18 weeks, with the end of study (EOS) at week 26. Safety was assessed through adverse events (AEs) and serious adverse events (SAEs).
Spatiotemporal modeling reveals high-resolution invasion states in glioblastoma.
Genome Biol
October 2024
Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada.
Article Synopsis
- Understanding the diffuse invasion of glioblastoma cells is crucial for addressing tumor aggressiveness and resistance to treatment, which negatively impacts patient prognosis.
- The study utilizes a novel computational method to analyze GBM xenografts, distinguishing human tumor cells from the mouse tumor microenvironment (TME), resulting in a detailed overview of 15 tumor cell programs linked to invasion pathways.
- The findings suggest targeted interventions on tumor and TME components could lead to improved therapies by revealing compensatory mechanisms that might aid in developing more effective combination treatments.
Neurofilament light chain associates with IVH and ROP in extremely preterm infants.
Pediatr Res
September 2024
Learning and Leadership for Health Care Professionals, Institute of Health and Care Science at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Article Synopsis
- This study explores how neurofilament light chain (NfL), a marker for brain injury, relates to neurovascular issues in extremely preterm infants, specifically those born before 28 weeks gestational age.
- Researchers found that higher NfL levels in the first month after birth are associated with severe intraventricular hemorrhage (IVH) and retinopathy of prematurity (ROP), especially in infants born before 25 weeks gestational age.
- The results suggest that NfL could be a potential predictor of neonatal morbidities linked to a more porous blood-brain barrier, indicating the need for further research in this area.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!