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Drug Development.
Alzheimers Dement
December 2024
Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Background: Recruiting and retaining older adults for clinical trials is challenging, especially in low-resource settings. Such challenges led to a systematic exclusion of such participants from clinical trials, compromising the generalizability of the results obtained in high income countries.
Objective: Here we describe the strategies we used in the PROAME study for recruiting and retaining illiterate older adults from low socioeconomical levels in a non-pharmacological trial.
Drug Development.
Alzheimers Dement
December 2024
Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Background: Prodromal Alzheimer's disease (AD) clinical trials of candidate treatments enroll individuals with mild cognitive impairment (MCI) and biomarker evidence of AD. These trials require co-enrollment with a study partner and complex decision-making, weighing potential risks and benefits of participation. Some patients with MCI lack capacity to provide trial informed consent.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Department of Frailty - Center for Cognitive Disorders and Dementia, Catanzaro Lido, ASP Catanzaro, Catanzaro, Italy.
Background: Writing is a cortical function studied by the human science of Graphology, which allows the personal knowledge of the subject, and psychophysical conditions, both in healthy older people and in those affected by dementia. Graphologists and geriatricians can successfully cooperate with this.
Method: Five volunteers aged between 60 and 80 years old (3 women and 2 men) were enrolled after signing an informed consent.
Dementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
University of Wisconsin Madison School of Medicine & Public Health, Madison, WI, USA.
Background: People living with dementia (PLWD) are high utilizers of acute illness and emergency care, with over 50% of the more than 6 million people with Alzheimer's disease and Alzheimer's disease related dementia (ADRD) visiting an emergency department (ED) annually. While the ED plays an important role meeting the urgent and acute needs of PLWD and their caregivers, presence of ADRD is often not well recognized and ED visits are associated with significant adverse outcomes for PLWD. Despite these factors, research on the emergency care needs of PLWD is extremely limited.
View Article and Find Full Text PDFImplications of Biomaterials for Chronic Wounds.
Mini Rev Med Chem
January 2025
University of Bucharest, Faculty of Biology, DAFAB Department, Splaiul Independentei 91-95, Bucharest, R-050095, Romania.
The use of biomaterials in treating and managing chronic wounds represents a significant challenge in global healthcare due to the complex nature of these wounds, which are slow to heal and can lead to complications such as frequent infections and diminished quality of life for patients. Chronic wounds, which can arise from conditions like diabetes, poor circulation, and pressure sores, pose distinct challenges in wound care, necessitating the development of specialized dressings. The pathophysiology of chronic wounds is thoroughly examined in this article, with particular attention paid to the cellular and molecular defects at work and the therapeutic guidelines.
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