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The Determinants of Long-Term Outcomes After Colorectal Cancer Surgery: A Literature Review.
Cureus
December 2024
Emergency Department, Sandwell and West Birmingham NHS Trust, Birmingham, GBR.
Colorectal cancer (CRC) is a common malignancy associated with high mortality. Surgical care is an effective colorectal cancer management technique, and it is therefore crucial that a review of the determinants of patients' long-term outcomes after CRC surgery is conducted. This article aims to provide healthcare professionals and policymakers with insights into the determinants of long-term outcomes following CRC surgery while acknowledging the interconnected impact of the early recovery and post-operative periods.
View Article and Find Full Text PDFRepairing muscle with broccoli-derived sulforaphane: A preclinical evaluation for the treatment of mitochondrial myopathies.
Drug Discov Today
December 2024
Department of Health Sciences and Biostatistics, Swinburne University of Technology, Melbourne, Australia. Electronic address:
Skeletal muscle health relies on the production of adenosine triphosphate (ATP) in the mitochondria. ATP production is accompanied by oxidative phosphorylation, which generates reactive oxygen species (ROS). When there is an imbalance in ROS levels, oxidative stress and subsequent mitochondrial dysfunction, mitochondrial myopathies including sarcopenia, chronic progressive external ophthalmoplegia, and proximal myopathy can result.
View Article and Find Full Text PDFBackground/objective: Beta-alanine supplementation increases muscle carnosine content and also improves exercise capacity and performance in young adults, with mixed findings emerging from the few studies investigating its effects on older participants. Therefore, this study aimed to systematically review the evidence regarding the effects of beta-alanine on exercise capacity, muscle strength, and functional performance of older adults.
Methods: This systematic review was conducted following the specific methodological guidelines of the Preferred Report Items for Systematic Reviews and Meta-Analyses and the Physiotherapy Evidence Database scale.
Sarcopenia, characterized by an age-related progressive loss of muscle mass and strength, presents significant health concerns. Recommending dietary nutrition emerges as a viable strategy to counteract muscle deterioration. Vitamin A, indispensable throughout the human life cycle and unattainable through endogenous synthesis, necessitates intake via diet.
View Article and Find Full Text PDFThe Relationship Between Cr/CysC Levels and Short-Term Prognosis with Acute Ischemic Stroke: Findings from a Cohort Study.
World Neurosurg
December 2024
Department of Nursing, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China; Department of Emergency, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China.
Objective: Sarcopenia significantly impacts prognosis in patients with acute ischemic stroke (AIS). This study investigates the relationship between serum creatinine/serum cystatin C (Cr/CysC) levels and short-term prognosis in AIS patients, aiming to inform post-treatment strategies.
Methods: We analyzed AIS patients at the First Affiliated Hospital of the University of Science and Technology of China from January 2022 to January 2024.
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