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SGLT2 Inhibitor for Cardiac Protection in a Patient With Osimertinib-Responsive Advanced EGFR-Positive Lung Cancer.
JACC Case Rep
December 2024
Indiana University School of Medicine, Indianapolis, Indiana, USA.
An 85-year-old man with recently diagnosed metastatic EGFR+ lung adenocarcinoma treated with osimertinib presented after 1 month of therapy in decompensated congestive heart failure along with atrial fibrillation, prolonged QTc and acute kidney injury. Osimertinib was held. His hemodynamic status was optimized, and he was started on cardioprotective medications (losartan and metoprolol succinate), and LVEF recovered.
View Article and Find Full Text PDFA convergent mixed methods to study registration on kidney transplantation waiting list refusal by women and men on dialysis in France.
Sci Rep
November 2024
EHESP, CNRS, INSERM, Arènes - UMR 6051, RSMS - U1309 -, University Rennes, 35000, Rennes, France.
Not all patients on dialysis want to be registered on the kidney transplantation (KT) waiting list and undergo transplantation. The aim of this convergent mixed methods study was to determine the features of patients refusing to be registered on the KT waiting list and the reasons. Quantitative data on all 2017-2019 incident 18-85-year-old dialysis patients, eligible for KT, were extracted from the REIN registry in France.
View Article and Find Full Text PDF[Behavioral variant of frontotemporal dementia with stereotypic speech: a case report].
Rinsho Shinkeigaku
December 2024
Department of Neurology, Graduate School of Medicine, Mie University.
Article Synopsis
- An 85-year-old man with behavioral variant frontotemporal dementia displayed reduced spontaneous speech and stereotypic speech patterns, indicating a progressive language disorder over two years, accompanied by changes in eating behavior.
- MRI scans revealed atrophy in the left frontal lobe, particularly affecting the superior, middle, and inferior frontal gyrus, while brain imaging showed decreased blood flow in these regions and the left basal ganglia.
- The diagnosis of behavioral variant frontotemporal dementia was reached due to the patient's specific symptoms, the observed progression, and evidence of brain lesions, with the stereotypic speech deemed as non-meaningful recurrent utterances.
Olfactory Neuroblastoma With Divergent Differentiation: Contemporary Management of Unusual Pathology and Literature Review.
Ear Nose Throat J
November 2024
Division of Rhinology, Department of Otolaryngology-Head and Neck Surgery, University of Florida, Gainesville, FL, USA.
Olfactory neuroblastoma (ON; Esthesioneuroblastoma) is a malignant tumor that arises from the olfactory neuroepithelium. Very rarely, ON can histologically display a biphenotypic pattern, with only 7 cases reported in the literature to date. We describe a case of this poorly understood entity and review the patient's histology, pathology, and treatment.
View Article and Find Full Text PDFMethotrexate, Hydrocortisone, Vincristine, Sobuzoxane, and Etoposide Is an Effective Option for Relapsed T-cell Prolymphocytic Leukemia with Loss of CD52 Expression after Retreatment with Alemtuzumab.
JMA J
October 2024
Department of Hematology, Fukushima Medical University Aizu Medical Center, Aizuwakamatsu, Japan.
T-cell prolymphocytic leukemia (T-PLL) is a rare and highly aggressive mature T-cell neoplasm. Although the response rate to alemtuzumab, an anti-CD52 antibody, is high, it is difficult to cure the disease with this agent alone. Therefore, hematopoietic stem cell transplantation is recommended for eligible patients.
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