The present work aims to improve the reliability of shield jamming and lining damage risk assessment in squeezing ground by analysing the effects of creep on the evolution of rock pressure over time. The study is based on numerical simulations of typical mechanised tunnelling processes, generally consisting of shield advance phases alternating with shorter or longer standstills for lining installation, maintenance, etc A linear elastic-viscous plastic constitutive model based upon Perzyna's overstress theory is employed, which considers the time-dependency of plastic deformations via a single viscosity parameter. The investigations demonstrate the following: (i) shield loading during advance increases with increasing viscosity under certain conditions, which contradicts the common perception in many existing works that creep is thoroughly favourable for shield jamming; (ii) creep is thoroughly unfavourable for shield loading during long standstills and long-term lining loading, due to the additional viscoplastic ground deformations manifested over time; (iii) the commonly adopted simplifying assumption of continuous excavation with the gross advance rate is adequate only where standstills are very short (e.g., for lining erection during the stop-and-go shield tunnelling process), but otherwise underestimates the shield loading, even in cases of regular inspection and maintenance standstills lasting only a few hours. Two application examples, the Fréjus safety gallery and the Gotthard Base tunnel, demonstrate the need to consider creep and the accuracy of modelling tunnel construction by a semi-discrete approach, where only the very short standstills for lining erection are considered via an average advance rate, but longer standstills are explicitly simulated.
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http://dx.doi.org/10.1007/s00603-023-03505-x | DOI Listing |
Clin Infect Dis
January 2025
Professor of Medicine, Director, Institute for Therapeutic Innovation at University of Florida, Orlando, FL, USA.
Based on the fact that beta-lactam antibiotics demonstrate time-dependent killing, different dosing strategies have been implemented to increase the time that free (f) (unbound) antibiotic concentrations remain above the Minimal Inhibitory Concentration (MIC), including prolonged and continuous infusion. Multiple studies have been performed that compared continuous with traditional intermittent infusion to improve outcomes in patients with severe sepsis and/or septic shock. These studies have yielded inconsistent results for patients as measured by clinical response to treatment and mortality due to heterogeneity of included patients, pathogens, dosing strategies and the absence of Therapeutic Drug Monitoring (TDM).
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January 2025
Royal National Orthopaedic Hospital NHS Trust, Foot & Ankle Unit, Stanmore, United Kingdom.
Background: Ankle and hindfoot fusion in the presence of large bony defects represents a challenging problem. The purpose of this study was to evaluate outcomes of patients who underwent ankle-hindfoot fusions with impaction bone grafting (IBG) with morselized femoral head allograft to fill large bony void defects.
Methods: This was a 3-center, retrospective review of a consecutive series of 49 patients undergoing ankle or hindfoot fusions with femoral head IBG for filling large bony defects.
ACS Omega
January 2025
School of Chemical Engineering, Vellore Institute of Technology, Vellore, Tamil Nadu 632014, India.
This work explores the enhancement of EMI shielding efficiency of polyurethane (PU) foam by loading multiwall carbon nanotube (MWCNTs)-decorated hollow glass microspheres (HGMs). MWCNT was coated onto the HGM surface by a simple solution casting technique. The coated HGM particles were loaded in PU foams, resulting in an even dispersion of MWCNT in the foam struts, thereby forming an interconnected conductive network in the polymer matrix.
View Article and Find Full Text PDFMaterials (Basel)
January 2025
Department of Dental Techniques, "Carol Davila" University of Medicine and Pharmacy, 8, Eroii Sanitari Blvd., 050474 Bucharest, Romania.
Unlabelled: Mandibular reconstruction is essential for restoring both function and aesthetics after segmental resection due to tumoral pathology. This study aimed to conduct a comparative analysis of three reconstruction strategies for defects resulting from segmental mandibular resection, utilizing finite element analysis (FEA).
Methods: A digital model of the mandible was created from CBCT data and optimized for FEA.
Biomedicines
December 2024
Jean Lamour Institute, Department of Micro and Nanomechanics for Life, University of Lorraine, UMR 7198, 54011 Nancy, France.
Oral implantology faces a multitude of technical challenges in light of current clinical experience, underlining the need for innovation in implantable medical devices in both mechanical and biological terms. This study explores the influence of the thickness factor of calcium-doped zirconia (Ca-SZ) coatings deposited by PVD on their intrinsic mechanical properties and the determinism of the latter on adhesion to the TA6V alloy substrate after mechanical loading for applications in dental implantology. Three separate thicknesses of 250 nm, 450 nm and 850 nm were evaluated in terms of mechanical strength, modulus of elasticity and adhesion to the substrate, in accordance with ISO 20502:2005.
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