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saliva modulates inflammasome activation and facilitates flavivirus infection . | LitMetric

saliva modulates inflammasome activation and facilitates flavivirus infection .

iScience

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway Room 2W09, Bethesda, MD, USA.

Published: January 2024

AI Article Synopsis

Article Abstract

Mosquito borne flaviviruses such as dengue and Zika represent a major public health problem due to globalization and propagation of susceptible vectors worldwide. Vertebrate host responses to dengue and Zika infections include the processing and release of pro-inflammatory cytokines through the activation of inflammasomes, resulting in disease severity and fatality. Mosquito saliva can facilitate pathogen infection by downregulating the host's immune response. However, the role of mosquito saliva in modulating host innate immune responses remains largely unknown. Here, we show that mosquito salivary gland extract (SGE) inhibits dengue and Zika virus-induced inflammasome activation by reducing NLRP3 expression, Caspase-1 activation, and 1L-1β secretion in cultured human and mice macrophages. As a result, we observe that SGE inhibits virus detection in the early phase of infection. This study provides important insights into how mosquito saliva modulates host innate immunity during viral infection.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10770497PMC
http://dx.doi.org/10.1016/j.isci.2023.108620DOI Listing

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