Epigenetic alterations of tumor suppressor genes (TSG) involved in the onset and progression of Breast Cancer (BC) may serve as biomarkers for early detection and prediction of disease prognosis. We have herein tried to determine the methylation status of TSG, in our 50 BC patients and their association with clinicopathological parameters. The methylation status of the gene in fresh tissue samples from 50 patients with BC was assessed by methylation-specific polymerase chain reaction (MS-PCR). The mean age of BC patients was 49.30 ± 9.75 years. Of 50 BC samples tested, 21 (42%) had methylated gene. gene hypermethylation was significantly associated with age ≤ 50 years, premenopausal status and advanced BC stage. Multivariate analysis revealed a strong association between advanced BC stage (Stage III and Stage IV) and hypermethylation (P = 0.008, RR = 5.996, 95% CI = 1.581-22.739). methylation was significantly associated with Triple Negative BC (TNBC) (P = 0.045, OR = 4.181, 95% CI = 1.030-16.981). These findings indicate that hypermethylation frequently occurs in BC. Hypermethylation of in young, premenopausal, TNBC and with advance stage in BC patients suggests its association with aggressive BC.
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| http://dx.doi.org/10.1007/s13193-023-01780-2 | DOI Listing |
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