AI Article Synopsis
- The use of GLP-1 agonists like semaglutide is rising for weight loss and managing non-alcoholic steatohepatitis (NASH), but safety data for NASH cirrhotic patients is limited.
- A documented case showed a patient with NASH-cirrhosis experienced liver decompensation after rapid weight loss on semaglutide, leading to the need for liver transplant waitlisting.
- Following the cessation of semaglutide and nutritional support, the patient's condition improved, allowing her to be removed from the transplant list, emphasizing the importance of caution and further research in treating cirrhotic patients with these medications.
Article Abstract
There is rapidly increasing uptake of GLP-1 (glucagon-like peptide-1) agonists such as semaglutide worldwide for weight loss and management of non-alcoholic steatohepatitis (NASH). remains a paucity of safety data in the vulnerable NASH cirrhotic population. We report herein the first documented case of liver decompensation and need for liver transplant waitlisting in a patient with NASH-cirrhosis treated with semaglutide. Rapid weight loss led to the development of ascites and hepatic encephalopathy and an increase in the patients Model for Endstage Liver Disease-Na (MELD-Na) score from 11 to 22. Aggressive nutritional supplementation was commenced and the semaglutide was stopped. Over the following months she regained her weight and her liver recompensated and her MELD-Na decreased to 13, allowing her to be delisted from the transplant waitlist. This case serves as a cautionary tale to clinicians using semaglutide in the cirrhotic population and highlights the need for more safety data in this patient group.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10768411 | PMC |
| http://dx.doi.org/10.3748/wjg.v29.i47.6165 | DOI Listing |
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