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Appendicectomy versus antibiotics for acute uncomplicated appendicitis in children: an open-label, international, multicentre, randomised, non-inferiority trial.
Lancet
January 2025
Division of General and Thoracic Surgery, Hospital for Sick Children, Toronto, ON, Canada.
Background: Support for the treatment of uncomplicated appendicitis with non-operative management rather than surgery has been increasing in the literature. We aimed to investigate whether treatment of uncomplicated appendicitis with antibiotics in children is inferior to appendicectomy by comparing failure rates for the two treatments.
Methods: In this pragmatic, multicentre, parallel-group, unmasked, randomised, non-inferiority trial, children aged 5-16 years with suspected non-perforated appendicitis (based on clinical diagnosis with or without radiological diagnosis) were recruited from 11 children's hospitals in Canada, the USA, Finland, Sweden, and Singapore.
Precision Medicine in Congenital Heart Disease, Rheumatic Heart Disease, and Kawasaki Disease of Children: An Overview of Literature.
Cardiol Rev
May 2024
Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE.
Congenital heart disease and common acquired heart diseases like Kawasaki disease and rheumatic heart disease are prevalent cardiovascular conditions in children worldwide. Despite the availability of treatment options, they continue to be significant contributors to morbidity and mortality. Advancements in early diagnosis, improvements in treatment approaches, and overcoming resistance to available treatments are crucial to reduce morbidity.
View Article and Find Full Text PDFReal-world outcomes on myopia management efficacy of diverse segmented defocus optics (DSDO) and defocus incorporated multiple segments (DIMS) spectacle lenses in Chinese children: An initial 12-month prospective clinical study.
J Optom
January 2025
Department of Ophthalmology, Peking University People's Hospital, Beijing, China; Eye Diseases and Optometry Institute, Beijing, China; Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China; College of Optometry, Peking University Health Science Center, Beijing, China.
Purposes: To investigate the 12-month effectiveness of Diverse Segmented Defocus Optics (DSDO) and Defocus Incorporated Multiple Segments (DIMS) spectacle lenses in a real-world clinical population in myopic and pre-myopic Chinese children.
Methods: About 364 subjects prescribed DSDO or DIMS were enrolled. Axial length (AL) and cycloplegic spherical equivalent refraction (SER) changes over 12 months were measured.
Effectiveness of Braille and ATP Technique in Improving Oral Hygiene Status of Visually Impaired Children: An Interventional Study.
J Contemp Dent Pract
September 2024
Department of Public Health Dentistry, MES Dental College and Hospital, Malappuram, Kerala, India.
Aim: The study aimed to subject two groups of visually challenged children to Braille and audio-tactile performance (ATP) techniques of oral health education and compare the effectiveness of each technique through a comparison of OHI-S index scores.
Materials And Methods: 30 visually challenged children of 6-12 years belonging to a Government-aided blind school were divided into two study groups based on the method of oral health education ( = 15). Group I received oral hygiene instructions in Braille while group II received instructions through audio clips, tactile sensations of tooth models, and closely supervised performance of brushing technique.
Prenatal Perfluoroalkyl Substance Exposure in Association with Global Histone Post-Translational Methylation in 2-Year-Old Children.
Toxics
November 2024
Institute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University, Taipei 100, Taiwan.
Perfluoroalkyl substances (PFASs) have elimination half-lives in years in humans and are persistent in the environment. PFASs can cross the placenta and impact fetal development. Exposure to PFASs may lead to adverse effects through epigenetic mechanisms.
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