Six new iridoid glycosides were isolated from the ethyl acetate fraction of the whole plants of Willd. They were identified as -6--methoxycinnamoyl-10--acetyl scandoside acid methyl ester (), -6--methoxycinnamoyl-10--acetyl scandoside acid methyl ester (), -6--caffeoyl scandoside methyl ester (), -6---coumaroyl-6'--acetyl scandoside methyl ester (), -6---coumaroyl-6'--acetyl scandoside methyl ester (), and -6---coumaroyl-4'--acetyl scandoside methyl ester (). The structures of them were elucidated based on unambiguous spectroscopic data (UV, IR, HRESIMS, and NMR). They were screened for anti-inflammatory effect, antioxidant effect, antitumor effect, and neuroprotective effect and did not show potent activities.
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http://dx.doi.org/10.1080/10286020.2023.2293068 | DOI Listing |
Chem Commun (Camb)
January 2025
Department of Advanced Energy Materials, College of Materials Science and Engineering, Sichuan University, Chengdu, 610064, China.
A NaF-rich composite artificial interphase is generated relying on a simple chemical reaction by regulating methyl 2,2,2-trifluoromethyl ester reactivity, which can promote rapid ion transport and effectively inhibit dendrite growth in carbonate electrolytes. The assembled NaF@Na‖NaV(PO) full cell attains a long lifespan of 4000 cycles at 5C with 95% capacity retention, and a high specific capacity of 80.8 mAh g at 30C.
View Article and Find Full Text PDFMycologia
January 2025
Crops Pathology and Genetics Research Unit, USDA-ARS Davis, Davis, California 95616.
Fungal trunk diseases are of major concern for tree fruit, nut, and grape growers throughout the world. These diseases include Eutypa dieback of grape, caused by , band canker of almond, caused by and , and twig and branch dieback of walnut, caused by , Botryosphaeria dieback of grape, caused by , and , and esca of grape, caused by and . Given the common occurrence of mixed infections, and the similar wood symptoms at the macroscopic level, species-specific detection tools are needed.
View Article and Find Full Text PDFWorld J Microbiol Biotechnol
January 2025
Department of Chemistry, Prince Mohammad Bin Fahd University, Al-Khobar, Saudi Arabia.
Sustainable management of textile industrial wastewater is one of the severe challenges in the current regime. It has been reported that each year huge amount of textile industry discharge especially the dye released into the environment without pre-treatment that adversely affect the human health and plant productivity. In the present study, different bacterial isolates had been isolated from the industrial effluents and investigated for their bioremediation potential against the malachite green (MG) dye, a major pollutant of textile industries.
View Article and Find Full Text PDFChem Biodivers
January 2025
Bezmialem Vakif University: Bezmialem Vakif Universitesi, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Vatan St., 34093, Istanbul, TURKEY.
In this study, a series of 16 arylidenehydrazide derivatives (7a-7p), hybridized with the natural product carvacrol, were successfully synthesized starting from anthranilic acid methyl ester. The cytotoxic effects of these compounds were examined against two different cell lines, A549 and BEAS-2B. Additionally, in silico studies were conducted to investigate the ligand-protein binding modes and their stabilities.
View Article and Find Full Text PDFMol Oncol
January 2025
Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Italy.
Specific reactive oxygen species activate the GTPase Kirsten rat sarcoma virus (KRAS) by reacting with cysteine 118 (C118), leading to an electron transfer between C118 and nucleoside guanosine diphosphate (GDP), which causes the release of GDP. Here, we have mimicked permanent oxidation of human KRAS at C118 by replacing C118 with aspartic acid (C118D) in KRAS to show that oncogenic mutant KRAS is selectively inhibited via oxidation at C118, both in vitro and in vivo. Moreover, the combined treatment of hydrogen-peroxide-producing pro-oxidant paraquat and nitric-oxide-producing inhibitor N(ω)-nitro-l-arginine methyl ester selectively inhibits human mutant KRAS activity by inducing oxidization at C118.
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