AI Article Synopsis
- Circadian clocks have evolved in various organisms to adapt to daily changes in light and temperature due to Earth's rotation, helping synchronize behavior and physiology with environmental rhythms.
- The cyanobacterial clock is a key model for studying circadian rhythms, as it can be fully reconstructed outside of living organisms.
- Recent advancements in biochemical, biophysical, and mathematical techniques have improved our understanding of the molecular mechanisms of cyanobacterial Kai proteins, offering insights that may help answer ongoing questions in circadian biology.
Article Abstract
Circadian clocks evolved in diverse organisms as an adaptation to the daily swings in ambient light and temperature that derive from Earth's rotation. These timing systems, based on intracellular molecular oscillations, synchronize organisms' behavior and physiology with the 24-h environmental rhythm. The cyanobacterial clock serves as a special model for understanding circadian rhythms because it can be fully reconstituted in vitro. This review summarizes recent advances that leverage new biochemical, biophysical, and mathematical approaches to shed light on the molecular mechanisms of cyanobacterial Kai proteins that support the clock, and their homologues in other bacteria. Many questions remain in circadian biology, and the tools developed for the Kai system will bring us closer to the answers.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10939747 | PMC |
| http://dx.doi.org/10.1016/j.tibs.2023.12.007 | DOI Listing |
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