AI Article Synopsis
- Thirteen new iridoid compounds (1-13) were discovered, along with five known ones (14-18), from the roots and rhizomes of the plant Valeriana jatamansi Jones.
- The structures of these compounds were determined using various analytical techniques, including MS, NMR, and circular dichroism spectra.
- Among the isolated compounds, 14, 16, and 17 demonstrated moderate protective effects against cell death in A549 cells, while 15 and 18 exhibited weak protective effects.
Article Abstract
Thirteen previously undescribed iridoids (1-13), together with five known iridoids (14-18) were isolated from the roots and rhizomes of Valeriana jatamansi Jones. Their structures with absolute configurations were elucidated by analysis of MS, NMR, optical rotation and their experimental and calculated electronic circular dichroism spectra. All of the isolated compounds were tested for their protective effects against α-hemolysin-induced cell death in A549 cells. Compounds 14, 16 and 17 showed moderate protective effects, and compounds 15 and 18 showed weak protective effects.
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| http://dx.doi.org/10.1016/j.phytochem.2023.113962 | DOI Listing |
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