Precise regulation of flowering time is critical for cereal crops to synchronize reproductive development with optimum environmental conditions, thereby maximizing grain yield. The plant-specific gene GIGANTEA (GI) plays an important role in the control of flowering time, with additional functions on the circadian clock and plant stress responses. In this study, we show that GI loss-of-function mutants in a photoperiod-sensitive tetraploid wheat background exhibit significant delays in heading time under both long-day (LD) and short-day photoperiods, with stronger effects under LD. However, this interaction between GI and photoperiod is no longer observed in isogenic lines carrying either a photoperiod-insensitive allele in the PHOTOPERIOD1 (PPD1) gene or a loss-of-function allele in EARLY FLOWERING 3 (ELF3), a known repressor of PPD1. These results suggest that the normal circadian regulation of PPD1 is required for the differential effect of GI on heading time in different photoperiods. Using crosses between mutant or transgenic plants of GI and those of critical genes in the flowering regulation pathway, we show that GI accelerates wheat heading time by promoting FLOWERING LOCUS T1 (FT1) expression via interactions with ELF3, VERNALIZATION 2 (VRN2), CONSTANS (CO), and the age-dependent microRNA172-APETALA2 (AP2) pathway, at both transcriptional and protein levels. Our study reveals conserved GI mechanisms between wheat and Arabidopsis but also identifies specific interactions of GI with the distinctive photoperiod and vernalization pathways of the temperate grasses. These results provide valuable knowledge for modulating wheat heading time and engineering new varieties better adapted to a changing environment.
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http://dx.doi.org/10.1111/tpj.16622 | DOI Listing |
Hernia
December 2024
University of Lund, Lund, Sweden.
Purpose: To investigate long-term chronic postoperative inguinal pain (CPIP), QoL and recurrence in patients with a primary inguinal hernia comparing TEP to Lichtenstein.
Material And Methods: A questionnaire-based follow-up containing the Inguinal Pain Questionnaire (IPQ), the Cunningham Pain Scale and SF-36 was done 8 years after the TEPLICH RCT. The main objective was non-ignorable pain last week according to IPQ.
Neural Netw
December 2024
State Key Lab of Brain-Machine Intelligence, Zhejiang University, China; College of Computer Science and Technology, Zhejiang University, China. Electronic address:
The spike-based neuronal responses within the ventral intraparietal area (VIP) exhibit intricate spatial and temporal dynamics in the posterior parietal cortex, presenting decoding challenges such as limited data availability at the biological population level. The practical difficulty in collecting VIP neuronal response data hinders the application of sophisticated decoding models. To address this challenge, we propose a unified spike-based decoding framework leveraging spiking neural networks (SNNs) for both generative and decoding purposes, for their energy efficiency and suitability for neural decoding tasks.
View Article and Find Full Text PDFCureus
November 2024
Department of General Surgery, Beckley Appalachian Regional Hospital, Beckley, USA.
Robotic cholecystectomy (RC) using the da Vinci surgical system has been introduced as a potential alternative to the gold standard laparoscopic cholecystectomy (LC) for gallbladder removal. This systematic review aims to evaluate and compare the postoperative outcomes (operative time, bile leak, and postoperative complications) and cost-effectiveness between da Vinci RC and LC. A comprehensive search of electronic databases, including EMBASE, MEDLINE, Cochrane Library, and PubMed, used Medical Subject Headings terms and Boolean operators to identify relevant studies.
View Article and Find Full Text PDFJ Med Internet Res
December 2024
Department of Biomedical Informatics, University at Buffalo, Buffalo, NY, United States.
Background: As of 2021, at least 4 out of every 5 hospitals offered patients access to clinical notes via a web-based patient portal, a number that is expected to grow because of the 21st Century Cures Act. There is limited data on how open note use may have evolved over time or which types of clinical interactions were viewed most in the outpatient setting.
Objective: This study aims to analyze trends in outpatient open note access over time; characterize usage in terms of age, sex, and clinical interaction type; and assess the method of access to help uncover areas of improvement in patient engagement and identify further areas of research.
Sensors (Basel)
December 2024
Department of Earth and Space Science and Engineering, Lassonde School of Engineering, York University, Toronto, ON M3J 1P3, Canada.
This research proposes a novel modeling method for integrating IMU arrays into multi-sensor kinematic positioning/navigation systems. This method characterizes sensor errors (biases/scale factor errors) for each IMU in an IMU array, leveraging the novel Generic Multisensor Integration Strategy (GMIS) and the framework for comprehensive error analysis in Discrete Kalman filtering developed through the authors' previous research. This work enables the time-varying estimation of all individual sensor errors for an IMU array, as well as rigorous fault detection and exclusion for outlying measurements from all constituent sensors.
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