AI Article Synopsis
- The study investigates the significance of microRNA miR-15a-5p in schizophrenia patients, finding elevated levels in their serum compared to healthy individuals.
- The research demonstrated that higher miR-15a-5p levels correlate positively with various schizophrenia symptoms, suggesting its potential as a diagnostic marker.
- An animal model confirmed that elevated miR-15a-5p is linked to cognitive and anxiety issues, supporting its role as a risk factor in the disorder.
Article Abstract
Background: More and more studies have confirmed that the heredity plays an important role in mental disorders, especially microRNA. The objective of this research was to explore the level of miR-15a-5p in patients with schizophrenia (SZ), and to evaluate the feasibility of this miRNA as a diagnostic marker of SZ.
Methods: The serum level of miR-15a-5p in patients with SZ and healthy people was detected by RT-qPCR. ROC curve was established to evaluate the clinical diagnostic significance of miR-15a-5p in SZ. Pearson correlation coefficient was used to evaluate the correlation between miR-15a-5p level and PANSS score. Logistic regression was used to assess the risk factors of SZ. A rat model of SZ was established, and the effects of miR-15a-5p on the behavior of SZ rats were observed through water maze test and open field test.
Results: The serum level of miR-15a-5p in patients with SZ was significantly increased, and ROC analysis revealed that miR-15a-5p had clinical diagnostic value in SZ. High level of miR-15a-5p was positively correlated with the positive symptom, negative symptom and general psychopathology subscore of patients. Logistic regression results showed that miR-15a-5p was a risk factor affecting the occurrence of SZ. Animal studies showed that the serum level of miR-15a-5p was elevated in the SZ rats, and inhibiting the expression of miR-15a-5p has a positive effect on improving the cognitive function and anxiety behavior of SZ rats.
Conclusions: Serum miR-15a-5p is a risk factor for SZ, which is of great significance for the diagnosis of SZ.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10768244 | PMC |
| http://dx.doi.org/10.1186/s12991-023-00489-4 | DOI Listing |
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