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Matters of the Heart: Cardiotoxicity Related to Target Therapy in Oncogene-Addicted Non-Small Cell Lung Cancer.
Int J Mol Sci
January 2025
Department of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO), Istituto di Ricovero e Cura a Carattere Scientifico, 33081 Aviano, Italy.
The treatment of Non Small Cell Lung Cancer (NSCLC) has been revolutionised by the introduction of targeted therapies. With the improvement of response and frequently of overall survival, however, a whole new set of adverse events emerged. In fact, due to the peculiar mechanism of action of each one of the tyrosine kinase inhibitors and other targeted therapies, every drug has its own specific safety profile.
View Article and Find Full Text PDFCerebral Amyloid Angiopathy in Alzheimer Disease: A Comparison Between Different Versions of the Boston Criteria.
Neurology
January 2025
Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy.
Objectives: Cerebral amyloid angiopathy (CAA) is the main driver of amyloid-related imaging abnormalities (ARIAs) in Alzheimer disease (AD). We compared different versions of the Boston criteria for CAA diagnosis in AD.
Methods: This article presents a single-center analysis (outpatient neurodegenerative clinic) of patients with AD with mild cognitive impairment (MCI) or early dementia, meeting NIA-AA criteria and having biological amyloid confirmation (CSF or imaging).
Development of the Whole Day Matters Toolkit for Primary Care: a consensus-building study to mobilize national public health guidelines in practice.
Health Promot Chronic Dis Prev Can
January 2025
School of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, Canada.
Introduction: Strategic knowledge mobilization efforts are needed to enhance uptake and use of the Canadian 24-Hour Movement Guidelines (24HMG), which describe optimal amounts of physical activity, sedentary behaviour and sleep each day for overall health. The Whole Day Matters Toolkit for Primary Care is an evidence-informed resource to help primary care providers (PCPs) disseminate the 24HMGs. The purpose of this study was to describe gaining consensus on toolkit components through iterative revisions to improve its utility in preparation for the September 2022 launch, and to summarize early dissemination efforts.
View Article and Find Full Text PDFHow social frailty is operationalized matters: Relationships with health and wellbeing in late adulthood.
Int Psychogeriatr
January 2025
School of Psychology, The University of Queensland, Brisbane, Australia.
Objectives: There are currently major inconsistencies in the methodological approaches used to index social frailty. The present study aimed to better understand which of these approaches may be most valuable in predicting older adult's physical health and psychological wellbeing.
Design: One hundred and thirty-three participants aged 60-90 years completed five measures commonly used to index social frailty, along with five measures of physical health, and psychological wellbeing.
The aging population presents critical challenges to global healthcare systems, with Japan expected to have 35% of its population aged 65 or older by 2040. Older adults often experience multimorbidity, cognitive impairments, and physical frailties, increasing healthcare utilization and costs. Traditional medical approaches that focus on organ-specific diagnoses are insufficient for addressing these multifaceted needs.
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