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The KRAS tour: Studying metabolic reprogramming in isogenic pancreatic cancer organoids. | LitMetric

Using an isogenic organoid platform to model pancreatic cancer, Duan et al. establish an important link between mutant KRAS and cholesterol metabolism and identify perhexiline maleate as a possible therapeutic to target this relationship.

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http://dx.doi.org/10.1016/j.stem.2023.12.010DOI Listing

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