AI Article Synopsis

  • Cannabis is increasingly popular for both medicinal and recreational use, leading to a rising interest in its chemical components and effects.
  • Current information on cannabis chemistry is often outdated or scattered, prompting the need for a more organized resource.
  • A new Cannabis Compound Database has been created using modern metabolomics and bioinformatics techniques to compile detailed information on over 6000 chemical constituents, making it a centralized and accessible tool for researchers and the cannabis community.

Article Abstract

Cannabis is widely used for medicinal and recreational purposes. As a result, there is increased interest in its chemical components and their physiological effects. However, current information on cannabis chemistry is often outdated or scattered across many books and journals. To address this issue, we used modern metabolomics techniques and modern bioinformatics techniques to compile a comprehensive list of >6000 chemical constituents in commercial cannabis. The metabolomics methods included a combination of high- and low-resolution liquid chromatography-mass spectrometry (MS), gas chromatography-MS, and inductively coupled plasma-MS. The bioinformatics methods included computer-aided text mining and computational genome-scale metabolic inference. This information, along with detailed compound descriptions, physicochemical data, known physiological effects, protein targets, and referential compound spectra, has been made available through a publicly accessible database called the Cannabis Compound Database (https://cannabisdatabase.ca). Such a centralized, open-access resource should prove to be quite useful for the cannabis community.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11212042PMC
http://dx.doi.org/10.1021/acs.jafc.3c06616DOI Listing

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