This investigation aimed to develop a voriconazole-loaded chitosan-coated cationic microemulsion (CVME) to treat fungal keratitis. Microemulsions were prepared using water titration, and the optimized microemulsion was coated with chitosan to prepare CVME. The physicochemical parameters, ocular irritation potential, antifungal efficacy and release studies were performed. The antifungal efficacy study was conducted in a fungal infection-induced rabbit eye model. The developed CVME displayed acceptable physicochemical properties and excellent mucoadhesive behavior and showed a sustained release profile. and studies concluded that higher permeability and improved antifungal efficacy were observed for CVME than drug suspension (DS). The prepared CVME7 is a viable alternative to treating fungal keratitis with existing approaches.
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| http://dx.doi.org/10.4155/tde-2023-0069 | DOI Listing |
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