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Preventive vs. Therapeutic Effects of Shoutai Wan: Maintaining an Acidic Microenvironment at the Maternal-Fetal Interface to Promote Angiogenesis and Minimize Pregnancy Loss in RSA Mice.
J Ethnopharmacol
January 2025
College of Integrated Traditional Chinese and Western Medicine, Hebei University of Chinese Medicine, Shijiazhuang, 050091, China; Collaborative Innovation Center of Integrated Chinese and Western Medicine on Reproductive Disease, Shijiazhuang, 050091, China; Hebei Key Laboratory of Integrative Medicine on Liver-kidney Patterns, Shijiazhuang, 050091, China. Electronic address:
Ethnopharmacological Relevance: The classic TCM prescription, Shoutai Wan (STW), is extensively used in clinical settings to manage threatened miscarriage and Recurrent spontaneous abortion (RSA). The complexity of pregnancy physiology, coupled with diverse etiologies, and the specificity of energy metabolism for normal embryo attachment and development,pose challenges to clinical diagnosis and treatment. The specific molecular mechanisms of how STW regulates these biological processes and contributes to the treatment of RSA remain to be elucidated.
View Article and Find Full Text PDFLigand-based cheminformatics and free energy-inspired molecular simulations for prioritizing and optimizing G-protein coupled receptor kinase-6 (GRK6) inhibitors in multiple myeloma treatment.
Comput Biol Chem
January 2025
Drug Discovery and Development Laboratory (DDD Lab), Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India. Electronic address:
Multiple myeloma (MM) is the second most frequently diagnosed hematological malignancy, presenting limited treatment options with no curative potential and significant drug resistance. Recent studies involving genetic knockdown established the crucial role of GRK6 in upholding the viability of MM cells, emphasizing the need to identify potential inhibitors. Computational exploration of GRK6 inhibitors has not been attempted previously.
View Article and Find Full Text PDFOptimizing cryptographic protocols against side channel attacks using WGAN-GP and genetic algorithms.
Sci Rep
January 2025
Department of Computer Science and Engineering, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India.
This research introduces a novel hybrid cryptographic framework that combines traditional cryptographic protocols with advanced methodologies, specifically Wasserstein Generative Adversarial Networks with Gradient Penalty (WGAN-GP) and Genetic Algorithms (GA). We evaluated several cryptographic protocols, including AES-ECB, AES-GCM, ChaCha20, RSA, and ECC, against critical metrics such as security level, efficiency, side-channel resistance, and cryptanalysis resistance. Our findings demonstrate that this integrated approach significantly enhances both security and efficiency across all evaluated protocols.
View Article and Find Full Text PDFA Holistic Digital Health Framework to Support Health Prevention Strategies in the First 1000 Days.
JMIR Pediatr Parent
January 2025
Center for Digital Health & Wellbeing, Fondazione Bruno Kessler, Trento, Italy.
The first 1000 days of a child's life, spanning from the time of conception until 2 years of age, are a key period of laying down the foundations of optimum health, growth, and development across the lifespan. Although the role of health prevention programs targeting families and children in the first 1000 days of life is well recognized, investments in this key period are scarce, and the provision of adequate health care services is insufficient. The aim of this viewpoint is to provide a holistic digital health framework cocreated with policy makers, health care professionals, and families to support more effective efforts and health care programs dedicated to the first 1000 days of life as the first line of prevention.
View Article and Find Full Text PDFComplete mitochondrial genome assembly and comparative analysis of Colocasia esculenta.
BMC Plant Biol
January 2025
Vegetable Research Institute, Guangxi Academy of Agricultural Sciences, Nanning, Guangxi, 530007, China.
Colocasia esculenta ranks as the fifth most important tuber crop and is known for its high nutritional and medicinal value. However, there is no research on its mitochondrial genome, hindering in-depth exploration of its genomic resources and genetic relationships. Using second- and third-generation sequencing technologies, we assembled and annotated the mitogenome of C.
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