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http://dx.doi.org/10.1038/s43588-023-00585-1 | DOI Listing |
Profiles Drug Subst Excip Relat Methodol
January 2025
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia.
This comprehensive drug profile provides a detailed exploration of Dronedarone, an antiarrhythmic medication used for regulating irregular heartbeats. This chapter covers various aspects of Dronedarone, including its nomenclature, formulae, physical characteristics, methods of preparation, and analytical methods. The nomenclature section presents the IUPAC and nonproprietary names of Dronedarone, along with its proprietary names.
View Article and Find Full Text PDFArXiv
November 2024
Division of Intramural Research, National Library of Medicine (NLM), National Institutes of Health (NIH), Bethesda, MD, USA.
Although large language models (LLMs) have been assessed for general medical knowledge using medical licensing exams, their ability to effectively support clinical decision-making tasks, such as selecting and using medical calculators, remains uncertain. Here, we evaluate the capability of both medical trainees and LLMs to recommend medical calculators in response to various multiple-choice clinical scenarios such as risk stratification, prognosis, and disease diagnosis. We assessed eight LLMs, including open-source, proprietary, and domain-specific models, with 1,009 question-answer pairs across 35 clinical calculators and measured human performance on a subset of 100 questions.
View Article and Find Full Text PDFInt J Nurs Stud
December 2024
School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China.; Research Centre for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Hong Kong SAR, China.; Joint Research Centre for Primary Health Care, The Hong Kong Polytechnic University, Hong Kong SAR, China.. Electronic address:
Background: Effective management of physical and psychological symptoms is a critical component of comprehensive care for both chronic disease patients and apparently healthy individuals experiencing episodic symptoms. Conversational agents, which are dialog systems capable of understanding and generating human language, have emerged as a potential tool to enhance symptom management through interactive support.
Objective: To examine the characteristics and effectiveness of conversational agent-delivered interventions reported in randomized controlled trials (RCTs) in the management of both physical and psychological symptoms.
SLAS Technol
January 2025
Cell Line Development, WuXi Biologics, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
Laboratory automation in the biopharmaceutical industry as a rule requires contracted service from highly professional automation solution provider, at times involving the purchase and development of specialized or customized hardware and software, which can be proprietary and expensive. Alternatively, with the availability of open-source software customized for automation, it is possible to automate existing laboratory instruments in a do-it-yourself (DIY), low-cost, and flexible fashion. In this work, we used an open-source scripting language, AutoIt, to integrate an existing microplate imager into an existing automation platform that is already equipped with a 4-axis robotic arm and an automated incubator, to achieve automation of the imaging procedure in our cell line development workflow.
View Article and Find Full Text PDFJ Am Med Inform Assoc
December 2024
Department of Radiology, Stanford University, Stanford, CA 94304, United States.
Objective: Brief hospital course (BHC) summaries are clinical documents that summarize a patient's hospital stay. While large language models (LLMs) depict remarkable capabilities in automating real-world tasks, their capabilities for healthcare applications such as synthesizing BHCs from clinical notes have not been shown. We introduce a novel preprocessed dataset, the MIMIC-IV-BHC, encapsulating clinical note and BHC pairs to adapt LLMs for BHC synthesis.
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