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Accelerated full-thickness skin wound tissue regeneration by self-crosslinked chitosan hydrogel films reinforced by oxidized CNC-AgNPs stabilized Pickering emulsion for quercetin delivery.
J Nanobiotechnology
June 2024
Department of Biomedical Science & Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Background: The non-toxic self-crosslinked hydrogel films designed from biocompatible materials allow for controlled drug release and have gathered remarkable attention from healthcare professionals as wound dressing materials. Thus, in the current study the chitosan (CS) film is infused with oil-in-water Pickering emulsion (PE) loaded with bioactive compound quercetin (Qu) and stabilized by dialdehyde cellulose nanocrystal-silver nanoparticles (DCNC-AgNPs). The DCNC-AgNPs play a dual role in stabilizing PE and are involved in the self-crosslinking with CS films.
View Article and Find Full Text PDFA sacred bond.
J Clin Neurosci
February 2024
Pontifical University Catholic of Parana, Medical School, Internal Medicine Department, Curitiba PR, Brazil; Rua General Carneiro 181, Centro, Curitiba, PR 80060-000, Brazil. Electronic address:
Analysis of the Dong bao Ye as sacred landscape and its Putative therapeutic mechanisms.
Health Place
September 2023
College of Built Environment, University of Washington, Seattle, WA, 98195, USA. Electronic address:
Humans have innately established close and profound ties with the, and through these relationships shaped many kinds of landscapes. Among these are sacred landscapes, which have drawn the attention of researchers due to their cultural significance. In the field of health geography, large-sized sacred regional landscapes are now the focus of studies for their therapeutic properties.
View Article and Find Full Text PDFRevealing the structural and molecular interaction landscape of the favipiravir-RTP and SARS-CoV-2 RdRp complex through integrative bioinformatics: Insights for developing potent drugs targeting SARS-CoV-2 and other viruses.
J Infect Public Health
July 2023
Institute for Skeletal Aging & Orthopaedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si 24252, Gangwon-do, Republic of Korea.
Background: The global research community has made considerable progress in therapeutic and vaccine research during the COVID-19 pandemic. Several therapeutics have been repurposed for the treatment of COVID-19. One such compound is, favipiravir, which was approved for the treatment of influenza viruses, including drug-resistant influenza.
View Article and Find Full Text PDFUltrasound assisted Cu-catalyzed Ullmann-Goldberg type coupling-cyclization in a single pot: Synthesis and evaluation of 11-pyrido[2,1-]quinazolin-11-ones against SARS-CoV-2 RdRp.
J Mol Struct
May 2023
Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Hyderabad 500046, India.
The evaluation of 11-pyrido[2,1-]quinazolin-11-one derivatives against SARS-CoV-2 RdRp was undertaken based on the reports on antiviral activities of this class of compounds in addition to the promising interactions of the antiviral drug penciclovir as well as quinazoline derivatives with SARS-CoV-2 RdRp . The target compounds were prepared an Ullmann-Goldberg type coupling followed by the subsequent cyclization (involving amidation) in a single pot. The methodology involved a CuI-catalyzed reaction of 2-iodobenzoate ester with 2-aminopyridine or quinolin-2-amine or thiazol-2-amine under ultrasound to give the expected products in acceptable (51-93%) yields.
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