This case concerns a 56-year-old female without medical history, who presents with a purple-red discoloration of the nose without clinical signs of sepsis. The patient rapidly deteriorates into multi-organ failure based on a pneumococcal sepsis with purpura fulminans.
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[A woman with a purple-red nose].
Ned Tijdschr Geneeskd
December 2023
Maasstad Ziekenhuis, afd. Interne Geneeskunde, Rotterdam.
This case concerns a 56-year-old female without medical history, who presents with a purple-red discoloration of the nose without clinical signs of sepsis. The patient rapidly deteriorates into multi-organ failure based on a pneumococcal sepsis with purpura fulminans.
View Article and Find Full Text PDFKaposi Sarcoma Associated with Tofacitinib Use in a Patient with Rheumatoid Arthritis.
R I Med J (2013)
August 2023
Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, RI.
Kaposi sarcoma is a rare vascular malignancy associated with HHV-8 infection. Four variants of Kaposi sarcoma have been described: Classic, African, HIV-associated, and iatrogenic. Iatrogenic Kaposi sarcoma is typically associated with immunosuppression and organ transplantation.
View Article and Find Full Text PDFAge-related changes of color visual acuity in normal eyes.
PLoS One
January 2022
Chukyo Eye Clinic, Nagoya, Japan.
Purpose: To evaluate the age-related change in color visual acuity (CVA) in normal eyes.
Methods: In total, 162 normal eyes (162 subjects, women: 52, men: 110, age range: 15-68 years) with best-corrected visual acuity (BCVA) ≥20/13 were enrolled. Fifteen colors from the New Color Test (chroma 6) were applied to Landolt "C" rings, white point D65 was applied as background, and a luminance of 30 cd/m2 was set for both the rings and the background.
Lichen planus-like lesion preceding bullous pemphigoid development after programmed cell death protein-1 inhibitor treatment.
J Dermatol
March 2021
Department of Dermatology, Kurume University School of Medicine, Fukuoka, Japan.
Immune checkpoint inhibitors including programmed cell death protein 1 (PD-1) antibody are used in major breakthrough therapies in cancer, however they cause unique adverse events, termed immune-related adverse events (irAEs). Among the various dermatological irAEs, an autoimmune bullous disease, bullous pemphigoid (BP), the hallmarks of which are circulating autoantibodies to epidermal basement membrane zone (BMZ) including BP180, have been noted. However, the mechanism and timing of autoantibody production in PD-1 inhibition remains unclear.
View Article and Find Full Text PDFPenile Angiokeratomas (PEAKERs) Revisited: A Comprehensive Review.
Dermatol Ther (Heidelb)
August 2020
San Diego Family Dermatology, National City, CA, USA.
Article Synopsis
- Angiokeratomas are benign vascular lesions found in the genital region, particularly on the scrotum for men and vulva for women, with specific subtypes known as PEGAKER and CLANKER for men and women, respectively.
- A study reviewed 54 cases of PEAKER in men, noting that they typically occur in younger males, often presenting with symptoms like bleeding, and are mostly found on the glans penis and penile shaft.
- Treatment options primarily included laser therapy, while some patients opted for other methods or chose to monitor the condition without intervention, with a recurrence rate noted after certain treatments.
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