AI Article Synopsis
- A case of refractory acute myeloid leukemia was observed, characterized by a specific DEK-NUP214 genetic rearrangement.
- The leukemic cells displayed unusual circulating monocytic blasts that contained numerous green cytoplasmic granules, as identified through Wright-Giemsa staining.
- These granules tested positive for hemosiderin, indicating possible siderophage activity linked to the differentiation of the leukemic monocytic blasts.
Article Abstract
We report a case of refractory acute myeloid leukemia with DEK-NUP214 rearrangement showing circulating monocytic blasts with abundant green cytoplasmic granules on the Wright-Giemsa stain. The granules were strongly positive for Perls' Prussian blue, consistent with hemosiderin deposits. This previously unreported finding is suggestive of siderophage activity by leukemic blasts, likely associated with monocytic differentiation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10766746 | PMC |
| http://dx.doi.org/10.1007/s12308-023-00555-6 | DOI Listing |
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