Objective: This study aimed to investigate the effects of low-intensity pulsed ultrasound (LIPUS) phonophoresis with diclofenac on inflammation and pain in the acute phase of carrageenan-induced arthritis in rats.
Design: 60 male Wistar rats were randomly divided into the arthritis, diclofenac, LIPUS, phonophoresis, and sham-arthritis control groups. LIPUS and transdermal diclofenac gel were applied to the lateral side of the inflamed knee for 7 days, initiated postinjection day 1. In the phonophoresis group, diclofenac gel was rubbed onto the skin, followed by LIPUS application over the medication. Knee joint transverse diameters, pressure pain thresholds (PPTs), and paw withdrawal thresholds (PWT) were evaluated. The number of CD68-, CD11c-, and CD206-positive cells, and IL-1β and COX-2 mRNA expression were analyzed 8 days after injection.
Results: In the phonophoresis group, the transverse diameter, PPT, PWT significantly recovered at the day 8 compared to those in the LIPUS and diclofenac groups. The number of CD68- and CD11c-positive cells in the phonophoresis group was significantly lower than that in the LIPUS and diclofenac groups, but no significant differences were observed among three groups in CD206-positive cells. IL-1β and COX-2 mRNA levels were lower in the phonophoresis group than in the arthritis group, although there were no differences among the LIPUS, diclofenac, and phonophoresis groups.
Conclusion: LIPUS phonophoresis with diclofenac is more effective to ameliorate inflammation and pain compared to diclofenac or LIPUS alone, and the mechanism involves the decrease of M1 macrophages.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10758990 | PMC |
| http://dx.doi.org/10.1016/j.ynpai.2023.100148 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of acetic acid shockwave phonophoresis on spur morphology, foot pain and function in patients with calcaneal spur: A randomised controlled trial.
Clin Rehabil
December 2024
Department of Physical Therapy for Basic Sciences, Faculty of Physical Therapy, Beni-Suef University, Beni-Suef, Egypt.
Objective: To investigate the effect of acetic acid shockwave phonophoresis on spur morphology, foot pain, and function in patients with calcaneal spurs.
Design: A double-blinded, randomised clinical trial.
Setting: Outpatients physical therapy clinics.
Effects of metformin phonophoresis and exercise therapy on pain, range of motion, and physical function in chronic knee osteoarthritis: randomized clinical trial.
J Orthop Surg Res
October 2024
Department of Physical Therapy for Musculoskeletal Disorders and its Surgeries, Faculty of Physical Therapy, Cairo University, Cairo, Egypt.
Background: Knee osteoarthritis (KOA) is a common musculoskeletal disorder. Therapeutic ultrasound (US) is a safe and effective treatment for KOA. It relieves knee pain and enhances function.
View Article and Find Full Text PDFUltrasound and Gold Nanoparticles Improve Tissue Repair for Muscle Injury Caused by Snake Venom.
Ultrasound Med Biol
January 2025
Laboratory of Pathophysiology Experimental, Postgraduate Program in Health Sciences, Universidade do Extremo Sul Catarinense, Criciúma, Brazil. Electronic address:
Article Synopsis
- - The study aimed to create a treatment to speed up recovery from tissue damage caused by Bothrops jararaca snake venom using ultrasound and gold nanoparticles (GNPs).
- - Researchers treated Swiss mice with various combinations of GNPs, ultrasound, and anti-bothropic serum after exposing them to snake venom, assessing factors like necrotic area and oxidative stress.
- - Results showed that treatments incorporating GNPs and ultrasound significantly reduced tissue damage, enhanced healing, and improved antioxidant responses in the body.
Efficacy and mechanism of gel for musculoskeletal injuries.
Am J Transl Res
May 2024
Department of Pathobiology and Biomedical Sciences, MNS University of Agriculture Multan 60000, Pakistan.
Objective: Formulate a gel and test its scientific efficacy for treating musculoskeletal ailments with or without phonophoresis.
Methods: Gel was made from leaf extract (30:70 aqueous-methanolic). A pragmatic, community-based, double-blinded randomized clinical study (IRCT20230202057310N1) was undertaken on 380 pre-diagnosed individuals with 1st and 2nd-grade musculoskeletal injuries, divided into four parallel groups (n = 95 per group): Group I got phonophoresis-applied 10% gel.
Effectiveness of chitosan phonophoresis on ulnar nerve conduction velocity, pain relief, and functional outcomes for mild to moderate cubital tunnel syndrome: A double-blind randomized controlled trial.
J Hand Ther
December 2024
Faculty of Physical Therapy, Ahram Canadian University, Giza, Egypt. Electronic address:
Background: Cubital tunnel syndrome (CBTS) impairs hand function, with limited conservative options often leading to surgery. Chitosan neuroregenerative effects delivered via phonophoresis provide a rationale for testing this emerging treatment approach.
Purpose: The primary goal of this research was to assess the impact of chitosan phonophoresis on the conductivity of the ulnar nerve, as well as its effects on pain levels and functional outcomes in individuals diagnosed with mild to moderate CBTS.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!