Objective: Numerous studies have proposed using fecal calprotectin among many biomarkers associated with necrotizing enterocolitis (NEC) diagnosis. This study aimed to evaluate fecal calprotectin as an early marker for suspected NEC (stage 1) in infants fed exclusively breast milk.
Methods: We collected 20 stool samples from newborns admitted to the neonatal intensive care unit at Aswan University Hospital diagnosed with stage I NEC. We compared them with 20 samples from matched healthy newborns. Fecal calprotectin level was measured by enzyme-linked immunosorbent assay.
Results: Fecal calprotectin level was higher in cases than in the control group ( < 0.001). Also, there was a positive correlation between fecal calprotectin and C-reactive protein in the studied cases ( = 0.001). However, there were no correlations between fecal calprotectin and sex or postnatal age.
Conclusion: Fecal calprotectin levels increase in newborns with stage I NEC. Although not specific, its sensitivity suggests a role as a potential biomarker in the evaluation of suspected NEC.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10761025 | PMC |
| http://dx.doi.org/10.1080/08998280.2023.2277580 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of Infant Formula Supplemented With Prebiotics on the Gut Microbiome, Gut Environment, Growth Parameters, and Safety and Tolerance: A Systematic Review and Meta-Analysis.
Nutr Rev
January 2025
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, United States.
Context: Prebiotics are often added to infant formulas to mimic the benefits of oligosaccharides found in human milk.
Objective: This systematic review and meta-analysis evaluated the effects of prebiotic-supplemented cow's milk-based formula on the gut microbiota, gut environment, growth parameters, and safety and tolerance in infants ≤6 months old, compared with a standard formula or human milk comparator.
Data Sources: Searches were performed in the PubMed, Embase, Cochrane Central Register of Controlled Trials, and ProQuest Dissertations & Theses databases.
Helicobacter pylori infection is associated with significant elevations to fecal calprotectin, systemic inflammatory markers.
J Pediatr Gastroenterol Nutr
January 2025
Department of Pediatrics, Division of Pediatric Gastroenterology, SUNY Downstate Health Sciences University, Brooklyn, New York, USA.
Objectives: Fecal calprotectin (FC) is a marker commonly used in the diagnosis and follow-up of inflammatory bowel diseases (IBD). However, other gastrointestinal conditions, like H. pylori (HP) infection, can result in increased neutrophil activity as well.
View Article and Find Full Text PDFPhysiological Data Collected from Wearable Devices Identify and Predict Inflammatory Bowel Disease Flares.
Gastroenterology
January 2025
The Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Background And Aims: Wearable devices capture physiological signals non-invasively and passively. Many of these parameters have been linked to inflammatory bowel disease (IBD) activity. We evaluated the associative ability of several physiological metrics with IBD flares and how they change before the development of flare.
View Article and Find Full Text PDFPalliative potential of genistein to counteract endosulfan instigated colon toxicity via regulating TLR4/MyD88, JAK1/STAT3 and NF-κB pathway: A biochemical and histological approach.
Tissue Cell
January 2025
Department of Zoology, Wildlife and Fisheries, University of Agriculture, Faisalabad, Pakistan. Electronic address:
Endosulfan (ESN) is an organophosphate insecticidal agent that is documented to induce various organ toxicities. Genistein (GEN) is a plant derived polyphenolic compound with excellent biological as well as pharmacological properties. This research was planned to assess the palliative potential of GEN to avert ENS prompted colonic toxicity.
View Article and Find Full Text PDFUrinary prostaglandin metabolites evaluation for activity monitoring in inflammatory bowel disease.
Sci Rep
January 2025
Clinical Biochemistry Laboratory, Beaujon Hospital, APHP, Clichy, France.
Inflammatory bowel diseases cause chronic intestinal inflammation, including Crohn's disease (CD) and ulcerative colitis (UC). Prostaglandin E-major urinary metabolite (PGE-MUM) is a urine biomarker for disease activity in IBD. This study evaluated PGE-MUM performance for predicting an active disease in patients with CD and UC.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!