AI Article Synopsis
- Recent advancements in tissue adhesives have led to the development of a new citrate-based polyurethane adhesive that addresses key limitations of existing options, such as weak adhesion in wet conditions and lack of bioactivity.
- This adhesive includes a hydrophobic layer made from polycaprolactone, enhancing bonding strength and allowing for rapid, non-invasive, and seamless closure of skin incisions.
- Importantly, it is biocompatible and biodegradable, with degradation products like citrate promoting wound healing and angiogenesis, thus offering a promising alternative to traditional sutures and tissues adhesives.
Article Abstract
As a superior alternative to sutures, tissue adhesives have been developed significantly in recent years. However, existing tissue adhesives struggle to form fast and stable adhesion between tissue interfaces, bond weakly in wet environments and lack bioactivity. In this study, a degradable and bioactive citrate-based polyurethane adhesive is constructed to achieve rapid and strong tissue adhesion. The hydrophobic layer was created with polycaprolactone to overcome the bonding failure between tissue and adhesion layer in wet environments, which can effectively improve the wet bonding strength. This citrate-based polyurethane adhesive provides rapid, non-invasive, liquid-tight and seamless closure of skin incisions, overcoming the limitations of sutures and commercial tissue adhesives. In addition, it exhibits biocompatibility, biodegradability and hemostatic properties. The degradation product citrate could promote the process of angiogenesis and accelerate wound healing. This study provides a novel approach to the development of a fast-adhering wet tissue adhesive and provides a valuable contribution to the development of polyurethane-based tissue adhesives.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10761209 | PMC |
| http://dx.doi.org/10.1093/rb/rbad101 | DOI Listing |
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