AI Article Synopsis
- PTEN is a tumor suppressor gene that regulates key cell signaling pathways and is often altered in various cancers, including salivary gland carcinomas (SGCs).
- SGCs show diverse histopathological characteristics and genetic imbalances, affecting their behavior and treatment responses.
- The review focuses on how PTEN deregulation influences the development and progression of SGCs, highlighting its importance in targeted therapies.
Article Abstract
Among the tumour suppressor genes that affect critically cell functions and homeostasis, phosphatase and tensin homolog deleted in chromosome 10 (PTEN- gene locus: 10q21) regulates the PI3K/Akt/mTOR signalling pathway. PTEN is deleted, mutated or epigenetically hyper-methylated in a variety of human solid malignancies. Salivary gland carcinomas (SGCs) belong to the head and neck carcinomas (HNCs) super category of solid malignancies. Histo-pathologically, they demonstrate a significant diversity due to a variety of distinct and mixed subtypes. Genetically, they are characterized by a broad spectrum of gene and chromosomal imbalances. Referring specifically to suppressor genes, PTEN deregulation plays a critical role in signaling transduction in the corresponding SGC pre- and malignant epithelia modifying the response rates to potential targeted therapeutic strategies. In the current review, we explored the role of PTEN deregulation mechanisms that are involved in the onset and progression of SGCs.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10758848 | PMC |
| http://dx.doi.org/10.21873/cdp.10280 | DOI Listing |
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