AI Article Synopsis
- Early diagnosis and treatment of CNS diseases is complicated by the blood-brain barrier, making research challenging.* -
- Brain-derived extracellular vesicles (EVs) contain specific proteins and RNAs that can serve as biomarkers for CNS diseases and be engineered to deliver therapeutic cargo.* -
- The text reviews advancements in using EVs for imaging, diagnosis, and treatment of neurological diseases, aiming to enhance their clinical application.*
Article Abstract
Early diagnosis and pharmacological treatment of central nervous system (CNS) diseases has been a long-standing challenge for clinical research due to the presence of the blood-brain barrier. Specific proteins and RNAs in brain-derived extracellular vesicles (EVs) usually reflect the corresponding state of brain disease, and therefore, EVs can be used as diagnostic biomarkers for CNS diseases. In addition, EVs can be engineered and fused to target cells for delivery of cargo, demonstrating the great potential of EVs as a nanocarrier platform. We review the progress of EVs as markers and drug carriers in the diagnosis and treatment of neurological diseases. The main areas include visual imaging, biomarker diagnosis and drug loading therapy for different types of CNS diseases. It is hoped that increased knowledge of EVs will facilitate their clinical translation in CNS diseases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10763486 | PMC |
| http://dx.doi.org/10.1186/s40001-023-01606-5 | DOI Listing |
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