AI Article Synopsis
- - Antibody-secreting plasma cells (PCs) develop in secondary lymphoid organs but can also be found in various tissues throughout the body, each with unique functional adaptations based on their environment.
- - Surprisingly, all tissue-resident plasma cells (TrPCs) exhibit long lifespans, which is influenced by internal factors such as the type of immunoglobulin they produce.
- - The bone marrow serves as a unique reservoir for PCs from different origins, preserving features of their original tissue's transcriptional programming, highlighting how their longevity is shaped by both initial signals and their current tissue environment.
Article Abstract
Antibody-secreting plasma cells (PCs) are generated in secondary lymphoid organs but are reported to reside in an emerging range of anatomical sites. Analysis of the transcriptome of different tissue-resident (Tr)PC populations revealed that they each have their own transcriptional signature indicative of functional adaptation to the host tissue environment. In contrast to expectation, all TrPCs were extremely long-lived, regardless of their organ of residence, with longevity influenced by intrinsic factors like the immunoglobulin isotype. Analysis at single-cell resolution revealed that the bone marrow is unique in housing a compendium of PCs generated all over the body that retain aspects of the transcriptional program indicative of their tissue of origin. This study reveals that extreme longevity is an intrinsic property of TrPCs whose transcriptome is imprinted by signals received both at the site of induction and within the tissue of residence.
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| http://dx.doi.org/10.1038/s41590-023-01712-w | DOI Listing |
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