AI Article Synopsis
- Anti-IgLON5 disease is characterized by various neurological symptoms, notably dysautonomia, which often does not respond to typical immunotherapy.
- A patient with this condition exhibited multiple autonomic failures, including severe vocal cord palsy, cognitive issues, and motor and gastrointestinal dysfunctions.
- However, after receiving combined immunotherapy, the patient's symptoms—including the vocal cord palsy—showed significant improvement, indicating potential benefits of this treatment approach for dysautonomia in anti-IgLON5 disease.
Article Abstract
Anti-IgLON5 disease shows various neurological manifestations, of which dysautonomia is one of the major symptoms and is rarely improved by immunotherapy. We herein report a patient with anti-IgLON5 disease who showed several autonomic failures, including vocal cord palsy for four months. The patient presented with cognitive impairments, bulbar symptoms accompanied by myorhythmia in the pharynx and tongue, cerebellar ataxia with tremor, motor neuron symptoms in the limbs, gastrointestinal dysfunction, orthostatic hypotension, non-rapid eye movement sleep disorder on polysomnography, and severe vocal cord palsy. Combined immunotherapy improved his symptoms, including vocal cord palsy, suggesting that combined immunotherapy might improve dysautonomia in anti-IgLON5 disease.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11358744 | PMC |
| http://dx.doi.org/10.2169/internalmedicine.2865-23 | DOI Listing |
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