AI Article Synopsis
- Polymer-based tissue adhesives (TAs) are emerging as alternatives to sutures for closing wounds due to their simplicity, cost-effectiveness, minimal tissue harm, and quick application time.
- Despite their advantages, TAs struggle with poor mechanical properties and weak adhesion strength, prompting research for improved versions with better performance.
- This review covers the essential features of polymeric TAs—including properties, assessment methods, mechanisms, applications, and commercial products—while highlighting polysaccharide-based TAs and discussing future developments.
Article Abstract
Recently, polymer-based tissue adhesives (TAs) have gained the attention of scientists and industries as alternatives to sutures for sealing and closing wounds or incisions because of their ease of use, low cost, minimal tissue damage, and short application time. However, poor mechanical properties and weak adhesion strength limit the application of TAs, although numerous studies have attempted to develop new TAs with enhanced performance. Therefore, next-generation TAs with improved multifunctional properties are required. In this review, we address the requirements of polymeric TAs, adhesive characteristics, adhesion strength assessment methods, adhesion mechanisms, applications, advantages and disadvantages, and commercial products of polysaccharide (PS)-based TAs, including chitosan (CS), alginate (AL), dextran (DE), and hyaluronic acid (HA). Additionally, future perspectives are discussed.
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| http://dx.doi.org/10.1016/j.carbpol.2023.121634 | DOI Listing |
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