Primary care pharmacist-led medication review in older adult patients in coordination with general practitioners: an observational retrospective cohorts study.

Background: Polypharmacy and risk of potentially inappropriate prescribing (PIP) in older adult are being continuously increased. Including a primary care pharmacist (PCP) in the healthcare team is associated with lower rates of medication-related problems (MRPs).

Objectives: To determine the impact (in terms of variation of PIP, MRPs and polymedication) of treatment reviews (TR) carried out by the PCP by comparing two cohorts: standard TR coordinated TR with prescribing General Practitioners (GP). To assess possible health outcomes in both groups 6 months post-TR.

Methods: This is an observational study of two retrospective cohorts (2018 to 2020). All patients who met the inclusion/exclusion criteria were analyzed. Patients ≥65 years, who underwent complete TR by the PCP were included. Patients in a situation of exitus at the time of TR and those who underwent a partial TR were excluded. Control group cohort consisted of patients who underwent standard TR, and intervention group cohort consisted of those who underwent TR coordinated with GP. Sociodemographic, clinical and pharmacological variables were analyzed.

Results: 181 patients were enrolled. Mean age 84.4 ± 7.2 years, 78.5% women. Variables (GP-coordinated standard TRs) pre-post: decrease in drugs/patient 1.9 (95%CI: 1.4-2.4) 0.6 (95%CI: 0.2-1.3),  < 0.05; decrease in MRPs/patient 3.1 (95%CI: 2.8-3.4) 1.0 (95%CI: 0.6-1.4), p < 0.05; decrease in PIP/patient 2.0 (95% CI: 1.6-2.2) 0.6 (95% CI: 0.2-0.9),  < 0.05. Health outcomes: there was significant difference in average primary-care visits/patient 1.3 ± 0.5 2.2 ± 1.8,  < 0.05.

Conclusions: Multidisciplinary interventions between PCP and GP, together with a systematic approach to TR can improve the quality of pharmacotherapy in the elderly. Prospective large follow-up studies are needed to demonstrate a positive trend in health outcomes.