AI Article Synopsis
- Posterior reversible encephalopathy syndrome (PRES) is a neurological condition that can result in symptoms like visual impairment, headaches, seizures, and altered consciousness, though its cause is not fully understood.
- A case report details a 49-year-old woman with advanced cervical carcinoma who developed PRES symptoms after starting treatment with anlotinib and tislelizumab, with diagnosis occurring 11 days into her treatment.
- After halting anlotinib and providing supportive care, she recovered her vision, and the likelihood of anlotinib being the cause of her condition was assessed as probable according to the Naranjo score.
Article Abstract
Posterior reversible encephalopathy syndrome (PRES), a neurological disorder with an unknown aetiology, is characterised by visual impairment, headache, vomiting, seizures, and transient alterations in consciousness. We present the case of a 49-year-old woman with advanced cervical carcinoma who received second-line therapy with oral anlotinib (12 mg, days 1-14, every 21 days) and injectable tislelizumab (200 mg, day 1, every 21 days). After 7 days of anlotinib administration, she began experiencing symptoms suggestive of PRES and was diagnosed on day 11. Interruption of anlotinib and supportive treatment led to recovery of her binocular vision. The Naranjo score (+5) graded the causality of this reaction as probable, suggesting the possibility that the event may have been an adverse reaction to anlotinib. This case report was approved by the Ethics Committee of the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine (Reference no. K-2023-068, 2023/06/09). Informed consent was obtained from the patient and her family.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10758437 | PMC |
| http://dx.doi.org/10.3389/fphar.2023.1255785 | DOI Listing |
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