as fungicide and symbiont: is it safe for human and animals?

species are considered as biological control agents against numerous phytopathogenic fungi. They are also helpful for plants as plant symbiont. This study aimed to identify harmful effects of in laboratory animals. In the first step, inhalation toxicity was studied. Six rats as control received a spray of bio-formulation without spores. Ten rats as treatment A received    1.00 × 10 colony-forming unit (CFU) of spores and ten rats as treatment B received 1.00 × 10 CFU per test of spores. The harmful effects of were obvious especially in the lungs, liver and kidney, and some blood parameters were abnormal. In the second step, we studied acute oral toxicity by gavage. Four rats as control received bio-formulation without spores. Six rats as treatment A received 1.00 × 10 CFU per test of spores. Six rats as treatment B received 1.00 × 10 CFU per test of spores. The harmful effects of were noticeable more in the liver and kidney tissues. For dermal toxicity study, two rabbits as control received bio-formulation without spores by rubbing on the surface of the skin. Treatment groups A and B received 1.00 × 10 and 1.00 × 10 CFU per test of spores, respectively (four rabbits for each group). The liver and kidney and some blood parameters were abnormal. has some harmful effects on tissues and organs and although it is a natural product, it should be used under cautions.